alexa The Expression of IgG and IgG4 in Lymphoma
ISSN: 2165-8048

Internal Medicine: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Expression of IgG and IgG4 in Lymphoma

Juan Li1,2 and Zhuoli Zhang1*
1Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China
2Department of Rheumatology, Shanxi Dayi Hospital, Shanxi Academy of Medical Sciences, Shanxi, China
*Corresponding Author : Zhuoli Zhang
Department of Rheumatology and Clinical Immunology
Peking University First Hospital, No.8
Xishiku Street West District
Beijing, 100034, People's Republic of China, China
Tel: +86-10-83572064
Fax: +86-10-83572064
E-mail: [email protected]
Received June 16, 2014; Accepted July 23, 2014; Published July 30, 2014
Citation: Li J, Zhang Z (2014) Expression of IgG and IgG4 in Lymphoma. Intern Med 4:164 doi:10.4172/2165-8048.1000164
Copyright: © 2014 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objectives: Although IgG4-related disease has been gradually recognized, its relationship with malignant diseases, especially lymphoma has been an eternal topic. Therefore we set out to explore the expression of IgG4 positive cells in lymphoma.

Methods: Surgical excision specimens with definite diagnosis of lymphoma from January to December, 2013 were collected. Hematoxylin-eosin staining and immunohistochemical staining of IgG and IgG4 were then evaluated on dense lymphoplasmacytic infiltration, storiform fibrosis and obliterative phlebitis. For the quantification of IgG and IgG4 positive cells, the areas with the highest density of positive cells were evaluated. Three high-powered fields (hpf) in each section were analyzed, and the average number of positive cells per hpf was calculated.

Results: 16 patients with lymphoma were included in our study. There were 9 males and 7 females with an average age of 51 years old. 3 cases were diagnosed as Hodgkin lymphoma while 13 were non-Hodgkin lymphoma (diffuse large B cell lymphoma 8 cases, small B cell lymphoma 2 cases, mucosa associated lymphoid tissue marginal zone B cell lymphoma (MALToma) 1 case, follicular lymphoma, peripheral T-cell lymphoma and hepatosplenic T-cell lymphoma 1 case. Dense lymphocytic infiltration accompanied by atypical lymphocytes was observed in all the specimens. Proliferation of fibrous tissue was only seen in one specimen. IgG positive cells were detectable in 14 cases with the highest cell count from 20-350/hpf. 2 Hodgkin lymphoma cases showed of IgG4 positivity with the highest cell counts were 11 and 12/hpf respectively.

Conclusion: IgG4 positive cells, fibrosis and obliterative phlebitis barely appeared in lymphoma. In combination with specific tumor signature molecules, it may not be difficult to distinguish lymphoma from IgG4-related disease.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords