The FDG-Uptake of Adipose Tissue is Higher in Individuals with Increased Blood Glucose Levels than in Individuals with Normal LevelsHenry Lindholm1*, Per Grybäck1, Alejandro Sánchez-Crespo2, Fredrik Brolin2 and Hans Jacobsson1
- Corresponding Author:
- Henry Lindholm
Department of Radiology
Karolinska University Hospital Solna
SE-171 76 Stockholm, Sweden
Tel: +46 70 626 6960
E-mail: [email protected]
Received Date: January 02, 2014; Accepted Date: March 10, 2014; Published Date: March 18, 2014
Citation: Lindholm H, Grybäck P, Crespo AS, Brolin F, Jacobsson H (2014) The FDG-Uptake of Adipose Tissue is Higher in Individuals with Increased Blood Glucose Levels than in Individuals with Normal Levels. J Nucl Med Radiat Ther 5:167. doi:10.4172/2155-9619.1000167
Copyright: © 2014 Lindhlom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract Objective: The influence of hyperglycaemia on the FDG uptake of regular adipose tissue at PET examinations was studied in clinical patients.
Methods: The report constitutes a sub-study of 500 consecutive clinical examinations evaluated in retrospect. The inclusion criteria comprised examinations with a normal, or a near normal FDG distribution. Patients who had been subjected to chemotherapy or radiotherapy <4 weeks prior to the examination were excluded. Otherwise, inclusion was made irrespective of concurrent diseases and/or therapy. In the current study, a sub-group of 62 patients with increased blood glucose levels (≥ 7.0 mmole/l) was compared with another 62 patients being paired with regard to age and gender and showing blood glucose levels within normal range (≤ 6.0 mmole/l). SUVmean of the axillary fat, perirenal fat, abdominal subcutis and gluteal fat were assessed. The gluteal fat was adequate for reliable evaluations. The other regions turned out more or less consistent for this because of the partial volume phenomenon, but were included because of the large number of observations, as well as no systematic influence on the outcome could be expected.
Results: There was a weak, but significantly higher FDG-uptake of all assessed adipose tissue depots in the patients showing increased blood glucose levels compared to the patients with normal blood glucose levels. The tracer uptake also varied between the different fat depots. This is in concordance with previous studies on insulinstimulated FDG-uptake showing differences of insulin resistance between various adipose tissue depots.
Conclusion: The uptake of FDG of adipose tissue is weakly increased in individuals with hyperglycemia compared to normal individuals. The differences are so small that they can be ignored in clinical practice.