alexa The Free Alpha-Hemoglobin: A Promising Biomarker for Ã
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

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Review Article

The Free Alpha-Hemoglobin: A Promising Biomarker for β-Thalassemia

Uday YH Abdullah1*, Ahmed GF Al-Attraqchi1, Hishamshah M Ibrahim2, Zilfalil Bin Alwi3, Atif A Baig1, Iekhsan Othman4, Noraesah B Mahmud2, Rosline B Hassan3, Nor Hedayah A Bakar1 and Alawiyah B A Abd Rahman5

1University Sultan Zainal Abidin (UniSZA), Faculty of Medicine and Health Sciences, Kuala Terengganu, Malaysia

2Hospital Kuala Lumpur (HKL), Kuala Lumpur, Malaysia

3Univesiti Sains Malaysia (USM), School of Medical Science, Kelantan, Malaysia

4Monash University, Selangor, Malaysia

5Hospital Sultana Nor Zahirah (HSNZ), Kuala Terengganu, Malaysia

*Corresponding Author:
Uday Younis Hussein Abdullah
University Sultan Zainal Abidin (UniSZA), Kampus Kota
Jalan Sultan Mahmud 20400, Kuala Terengganu,Malaysia
Tel: 609-625607
Fax: 60-6275771/5772
E-mail: [email protected]

Received Date: August 28, 2014; Accepted Date: September 27, 2014; Published Date: September 29, 2014

Citation: Abdullah UYH, Attraqchi AGFA, Ibrahim HM, Alwi ZB, Baig AA, et al. (2014) The Free Alpha-Hemoglobin: A Promising Biomarker for ß-Thalassemia. J Mol Biomark Diagn 5:197. doi:10.4172/2155-9929.1000197

Copyright: © 2014 Abdullah UYH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The purpose is to review the current knowledge and methods of determination of the free alpha hemoglobin with emphasis on its potential implications in patients with beta-thalassemia (ß-thal).The severity of ß-thal correlates with the extent of imbalance between a- and non-a-globin chains and the amount of the free alpha hemoglobin (free a-Hb) pool in the erythrocytes. To date, there is a lack of biomarkers that convey diagnostic and prognostic values in ß-thal. Our ongoing research is aimed to evaluate the potential prognostic and diagnostic implications of free a-Hb to improve the care of patients with ß-thal. Our ongoing research is aimed to quantify the free a-Hb for its potential prognostic and diagnostic implications towards improving the care of patients with various ß-thal types in the years to come.

 

Abstract

The purpose is to review the current knowledge and methods of determination of the free alpha hemoglobin with emphasis on its potential implications in patients with beta-thalassemia (β-thal).The severity of β-thal correlates with the extent of imbalance between α- and non-α-globin chains and the amount of the free alpha hemoglobin (free α- Hb) pool in the erythrocytes. To date, there is a lack of biomarkers that convey diagnostic and prognostic values in β-thal. Our ongoing research is aimed to evaluate the potential prognostic and diagnostic implications of free α-Hb to improve the care of patients with β-thal. Our ongoing research is aimed to quantify the free α-Hb for its potential prognostic and diagnosticimplications towards improving the care of patients with various β-thal types in the years to come.

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