alexa The Frequencies of Ten Platelet Polymorphisms Associate
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

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Research Article

The Frequencies of Ten Platelet Polymorphisms Associated with Atherosclerotic Cardiovascular Disease in Patients with Venous Thromboembolism: A Population-Based Case-Control Study

Kvasnicka T1, Bobcikova P1, Malikova I1, Hajkova J1, Zima T1, Ulrych J2, Briza J2, Brzezkova R1, Duskova D3, Poletinova S3, Kieferova V3 and Kvasnicka J1*

1Thrombotic Centre and Central Haematological Laboratory, Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

21st Surgical Department, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

3Faculty Department of Blood Transfusion, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

*Corresponding Author:
Kvasnicka Jan
Thrombotic Centre
Institute of Medical Biochemistry and Laboratory Diagnostics
General University Hospital, Charles University
Karlovo nám, 32, Prague 2, Czech Republic
Tel:
420224966413
Fax: 420224966414
E-mail: [email protected]

Received Date: July 14, 2015; Accepted Date: July 28, 2015; Published Date: July 31, 2015

Citation:Kvasnicka T, Bobcikova P, Malikova I, Hajkova J, Zima T, et al. (2015) The Frequencies of Ten Platelet Polymorphisms Associated with Atherosclerotic Cardiovascular Disease in Patients with Venous Thromboembolism: A Population- Based Case-Control Study. Hereditary Genet 4:153. doi:10.4172/2161- 1041.1000153

Copyright: ©2015 Kvasnicka T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Background: At present, atherosclerotic CardioVascular Disease (CVD) and the Vein ThromboEmbolism (VTE) are considered to have many common risk factors. The aim of our study was to determine the frequencies of ten platelet gene polymorphisms that were associated with atherosclerotic CVD in subjects (n=2369) with VTE in comparison with their frequencies in a control group (n=1460) of healthy persons. Methods: The polymorphisms of platelet receptors P2Y12 (rs2046934, rs6785930), GPIa (rs1126643), GP IIIa (rs5918), GP VI (rs1613662) and PAR-1(rs168753) and the variations in the genes coding for cyclooxygenase 1 (COX- 1; rs10306114) and platelet endothelial aggregation receptor 1 (PEAR1; (rs41299597, rs11264579, rs2768759) were determined. Results: The examinations did not show any significant differences between the polymorphism frequencies in subjects with VTE in comparison to the results obtained in control group of healthy persons. Only in the subgroup of VTE patients (n 732) with a family history of myocardial infarct and/or stroke were weakly significant increases in the “risk” genotype frequencies in GP Ia (rs1126643) and in PEAR1 (rs 11264579) (both p=0.04) observed, but no significant differences were noted in the allele frequencies. Conclusions: We suggest that the observed platelet gene polymorphisms play no significant role as independent hereditary risk factors in the pathogenesis of VTE.

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