alexa The Frequency of C677T Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism in Southern East Bosnian Population | OMICS International | Abstract
ISSN: 2155-6180

Journal of Biometrics & Biostatistics
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Research Article

The Frequency of C677T Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism in Southern East Bosnian Population

Karic Amela1*, Terzic Rifet1, Jerkic Zoran2 and Mustedanagic-Mujanovic Jasminka3

1Division of Genetics, Faculty of Science, University of Tuzla, Univerzitetska 4, 7500 Tuzla, Bosnia and Herzegovina

2Clinics for Cardiovascular Diseases, University Clinical centre Tuzla, Trnovac bb, 7500 Tuzla, Bosnia and Herzegovina

3Polyclinics for Laboratory Diagnostics, University Clinical centre Tuzla, Trnovac bb, 7500 Tuzla, Bosnia and Herzegovina

*Corresponding Author:
Karic Amela
Division of Genetics, Faculty of Science
University of Tuzla, Univerzitetska 4
7500 Tuzla, Bosnia and Herzegovina
Tel: +387 61 289 217
Fax: +387 35 320 861
E-mail: [email protected]

Received Date: July 18, 2013; Accepted Date: August 08, 2013; Published Date: August 14, 2013

Citation: Amela K, Rifet T, Zoran J, Jasminka MM (2013) The Frequency of C677T Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism in Southern East Bosnian Population. J Biomet Biostat 4:169. doi: 10.4172/2155-6180.1000169

Copyright: © 2013 Amela K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The C677T MTHFR polymorphism is distributed widely among ethnics populations and showing a high heterogeneity. The fact that there were no published data on the prevalence of C677T MTHFR polymorphism in Bosnia and Herzegovina prompted us to determine its prevalence in sample of Bosnian population.
Two hundred and seven unrelated, apparently healthy subjects from Southern east Bosnia were included in study. Genotyping of C677T MTHFR polymorphism was done using polymerase chain reaction (PCR) followed by restriction digestion (RFLP) with HinfI enzyme.
Out of 207 healthy subjects, 44.44% were heterozygous and 11.11% were homozygous for C677T MTHFR polymorphism. Allele and genotype frequency of MTHFR C677T did not differ between males and females carriers (X2=0.87; df=1; P=0.350).This study is the first to report frequency of C677T polymorphism in healthy Bosnian population. Frequency of the T allele and C677T MTHFR genotype observed in this study is consistent with the data from literature.

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