alexa The Function of Polycystin-1 and Polycystin-2 in Cardiovascular System
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
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Review Article

The Function of Polycystin-1 and Polycystin-2 in Cardiovascular System

Cong Qiu and Jun Yu*
Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, USA
Corresponding Author : Jun Yu, M.D.
Yale University School of Medicine
Section of Cardiovascular Medicine
Yale University School of Medicine
10 Amistad Street, New Haven
CT 06520, USA
Tel: 203 737-2869
E-mail: [email protected]
Received April 26, 2013; Accepted May 25, 2013; Published May 31 2013
Citation: Qiu C, Yu J (2013) The Function of Polycystin-1 and Polycystin-2 in Cardiovascular System. J Cardiovasc Dis Diagn 1:110. doi: 10.4172/2329-9517.1000110
Copyright: © 2013 Qiu C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Autosomal Dominant Polycystic Kidney Disease (ADPKD) caused by mutations in polycystic kidney disease
1 or 2 (Pkd1 or Pkd2) gene is the most common inherited renal disease and is characterized by cardiovascular abnormalities like hypertension and aneurysms. Polycystin-1 (PC1) and polycystin-2 (PC2), encoded by Pkd1 and Pkd2 genes, respectively, are detected in the cardiovascular system, indicating that PC1 or PC2 may play an important role in cardiovascular function. In the present review, we summarize current findings of PC1 and PC2 in cardiovascular regulation, such as hypertension and aneurysms associated with ADPKD and embryonic development.

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