alexa The Future Challenges for the Clinical Application of Reprogrammed Cells | OMICS International | Abstract
ISSN: 2161-0436

Human Genetics & Embryology
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Review Article

The Future Challenges for the Clinical Application of Reprogrammed Cells

Jordi Requena1, Ana Belen Alvarez Palomo1, Marti Farrera Sal1, John Christodoulou2, Josep M Canals3 and Michael J Edel1,4*

1 Control of Pluripotency Laboratory, Department of Physiological Sciences I, Faculty of Medicine, University of Barcelona, Hospital Clinic, Casanova 143, 08036, Barcelona, Spain

2 Western Sydney Genetics Program, The Children’s Hospital at Westmead, Disciplines of Paediatrics & Child Health and Genetic Medicine, Sydney Medical School, University of Sydney, Australia

3 Laboratori de Cellules Mare i Medicina Regenerativa, Departament Biologia Cellular, Immunologia i Neurociències, Programa de Terapia Cellular, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, Spain

4 Senior Research Fellow at the University of Sydney Medical School, Faculty of Medicine, Westmead Children’s Hospital, Division of Pediatrics and Child Health, Sydney, Australia

*Corresponding Author:
Michael J Edel
Senior Research Fellow at the University of Sydney Medical School
Faculty of Medicine, Westmead Children’s Hospital
Division of Pediatrics and Child Health
Sydney, Australia
Tel: 0034934024518
E-mail: [email protected]

Received January 15, 2014; Accepted February 19, 2014; Published March 10, 2014

Citation: Requena J, Palomo ABA, Sal MF, Christodoulou J, Canals JM, et al. (2014) The Future Challenges for the Clinical Application of Reprogrammed Cells. Human Genet Embryol 4:120. doi: 10.4172/2161-0436.1000120

Copyright: © 2014 Requena J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Recent developments in the field of reprogramming somatic cells to induced pluripotent stem cells (iPSC) has brought the field closer to the exciting possibility of their future clinical application. A number of challenges remain to be addressed before clinical application of reprogrammed stem cells becomes a reality. The main issues are the threat of cancer, control of differentiation to tissue specific stem cells or body organs and the immune response of iPSC-derived cells. The future use of iPSC will require that they are cancer free, do not proliferate and can be contained to the specific injection site for tissue regeneration. This review discusses the recent advances that address these main challenges in the field of cellular reprogramming


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