alexa The Haptogenic Pathogenesis of Vitiligo and the Source of the Pattern of Depigmentation
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
Open Access

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Previously: Journal of Pigmentary Disorders

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Review Article

The Haptogenic Pathogenesis of Vitiligo and the Source of the Pattern of Depigmentation

Patrick A Riley*
Totteridge Institute for Advanced Studies, London, UK
Corresponding Author : Patrick A Riley
Totteridge Institute for Advanced Studies
The Grange, Grange Avenue, London N20 8AB, UK
Tel: (+44) 20 8445 5687
Email: [email protected]
Received May 03, 2014; Accepted May 23, 2014; Published May 25, 2014
Citation: Patrick A Riley (2014) The Haptogenic Pathogenesis of Vitiligo and the Source of the Pattern of Depigmentation. Pigmentary Disorders 1:109. doi:10.4172/2376-0427.1000109
Copyright: © 2014 Riley PA, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The pathogenesis of vitiligo based on the model of depigmentation produced by topical application of phenolic compounds that are substrates for tyrosinase is outlined. The main steps in the pathway consist of the haptenation of melanosomal proteins by the quinone products of the analogue phenols with the generation of neo-antigens which are able to elicit a cell-mediated immune response that results in loss of melanocytes and consequent epidermal depigmentation. The source and nature of the haptogenic compounds is unknown but may be of dietary origin. It is suggested that the pattern of depigmentation in vitiligo is determined by regional variations in tyrosinase activity. The possibility of utilizingquinone-mediated haptenation as a means of targeting anti-melanoma immunotherapy is briefly discussed.

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