The Haptogenic Pathogenesis of Vitiligo and the Source of the Pattern of Depigmentation*Corresponding Author: Patrick A Riley, Totteridge Institute for Advanced Studies, The Grange, Grange Avenue, London N20 8AB, UK, Tel: (+44) 20 8445 5687, Email: [email protected]
Received Date: May 03, 2014 / Accepted Date: May 23, 2014 / Published Date: May 25, 2014
Citation: Patrick A Riley (2014) The Haptogenic Pathogenesis of Vitiligo and the Source of the Pattern of Depigmentation. Pigmentary Disorders 1:109.DOI: 10.4172/2376-0427.1000109
Copyright: © 2014 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The pathogenesis of vitiligo based on the model of depigmentation produced by topical application of phenolic compounds that are substrates for tyrosinase is outlined. The main steps in the pathway consist of the haptenation of melanosomal proteins by the quinone products of the analogue phenols with the generation of neo-antigens which are able to elicit a cell-mediated immune response that results in loss of melanocytes and consequent epidermal depigmentation. The source and nature of the haptogenic compounds is unknown but may be of dietary origin. It is suggested that the pattern of depigmentation in vitiligo is determined by regional variations in tyrosinase activity. The possibility of utilizingquinone-mediated haptenation as a means of targeting anti-melanoma immunotherapy is briefly discussed.