alexa The Hepatoprotective Effect of Diltiazem and Silymarin
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

The Hepatoprotective Effect of Diltiazem and Silymarin

Burczynski FJ1,2*, Yan J1, Gong Y1, Nguyen D1, Wang G3, Burczynski SD1, Smith HJ4 and Gong Y1
1Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba, Canada
2Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
3Carolinas Medical Center, Charlotte, NC, USA
4Howard J Smith & Associates Pty Ltd, Melb ourne, Australia
Corresponding Author : Burczynski FJ
Faculty of Pharmacy
University of Manitoba
750 McDermot Avenue, Winnipeg
Manitoba, R3E 0T5, Canada
Tel: (204)474-6902
Fax: (204)474-7617
E-mail: [email protected]
Received July 15, 2013; Accepted July 27, 2013; Published August 03, 2013
Citation: Burczynski FJ, Yan J, Gong Y, Nguyen D, Wang G, et al. (2013) The Hepatoprotective Effect of Diltiazem and Silymarin. Nat Prod Chem Res 1:111. doi: 10.4172/2329-6836.1000111
Copyright: © 2013 Burczynski FJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The clinical use of diltiazem has been suggested to be a reasonable approach for combating free radical induced liver damage. The hepatoprotective effect was observed with d-cis diltiazem but not with l-cis diltiazem, suggesting that diltiazem is stereospecific in protecting against lipid peroxidation using isolated microsomes. In the present work we examined d-cis diltiazem’s antioxidant property using Chang and PLC hepatocyte cultures, and the combination of diltiazem and silymarin since silymarin itself has been reported to possess hepatoprotectant properties. Diltiazem (5 and 10 μM) significantly reduced free radical levels, as did silymarin. The combination of diltiazem and silymarin further protected cells against oxidative stress (p<0.001) compared to either drug alone. Diltiazem, silymarin and the combination were associated with enhanced ATP and reduced Bax and Bax mRNA levels in both cell types with the combination drug treatment showing a much greater difference. The combination of dilitiazem and silymarin further enhanced cell viability. We conclude that low dose diltiazem and silymarin can function as a hepatoprotectant against free radical damage due to oxidative stress. The protective nature extends to reducing levels of the pro-apoptotic Bax protein.

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