The Heterochromatin Condensation State in Peripheral Ã¢ÂÂGene PoorÃ¢ÂÂ and Central Ã¢ÂÂGene RichÃ¢ÂÂ Nuclear Regions of Less Differentiated and Mature Human Leukemic Cells: A Mini-Review with Additional Original Observations
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
- *Corresponding Author:
- Karel Smetana
Senior scientist Institute of Hematology and Blood Transfusion
U nemocnice 1, 128 20 Prague, Czech Republic
Received date: May 22, 2014; Accepted date: August 28, 2014; Published date: August 30, 2014
Citation: Smetana K (2014) The Heterochromatin Condensation State in Peripheral “Gene Poor” and Central “Gene Rich” Nuclear Regions of Less Differentiated and Mature Human Leukemic Cells: A Mini-Review with Additional Original Observations. J Leuk (Los Angel) 2:151 doi: 10.4172/2329-6917.1000151
Copyright: © 2014 Karel Smenata. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the morphological cytology the heterochromatin is one of very useful tools for the cell identification including the differentiation and maturation stage. However, the heterochromatin condensation state was less studied although it appeared to be different in “gene rich” central and “gene poor” peripheral nuclear regions. The heavy heterochromatin condensation state in the central “gene rich” nuclear regions might reflect a marked structural stability and protect the genomic integrity. It must be also noted that the heterochromatin condensation state in these nuclear regions is more variable than in the nuclear periphery because of the presence of more as well as less condensed heterochromatin territories. On the other hand, the heterochromatin condensation state in the nuclear periphery markedly increases during the cell differentiation and maturation. In fully differentiated and mature cells the heavy heterochromatin condensation state is similar in both central and peripheral nuclear regions. The resulting ratio of the heterochromatin condensation state in central nuclear regions to the nuclear periphery is higher in less differentiated cells and then decreases during the maturation (terminal differentiation) process. That ratio facilitates to compare cells in different differentiation or maturation stages of various cell lineages because the estimated arbitrary density units are frequently variable depending on the background of the cell surrounding.