alexa The Historic Development and Incorporation of Four Assi
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
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Review Article

The Historic Development and Incorporation of Four Assisted Reproductive Technologies Shaping Todays IVF Industry

Mitchel C. Schiewe PhD*
Ovation Fertility, Newport Beach, CA USA
Corresponding Author : Mitchel C. Schiewe PhD
Ovation Fertility-NB, 361 Hospital Road
Suite 433, Newport Beach, CA,92663, USA
Tel: 01-949-642-5954
Fax: 01-949-642-2954
E-mail: [email protected]
Received February 11, 2016; Accepted February 29, 2016; Published March 07, 2016
Citation: Schiewe MC (2016) The Historic Development and Incorporation of Four Assisted Reproductive Technologies Shaping Today’s IVF Industry. J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol 4:173. doi:10.4172/2375- 4508.1000173
Copyright: © 2016 Schiewe MC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The concept of assisted reproductive technologies was most notably derived from the late 19th Century experiments of Sir Walter Heape who successfully transplanted rabbit embryos. Interestingly, it was not until the late 1940’s and 1950’s that renewed interests in rabbit embryo transfer and cryobiology occurred. The history behind developing effective procedures can be fascinating, though few could be more accidental than Dr. Chris Polge’s discovery of glycerol (1948), from a mislabeled bottle of sugar solutions, being an effective cryoprotective agent for sperm freezing. The purpose of this review paper is to discuss four key scientific breakthrough technologies occurring between 1985 and 1995, which ultimately shaped the future of today’s human in vitro fertilization (IVF) industry. More importantly, this paper highlights the foundation of underlying related discoveries and some unique stories involving their development and publication. In the end, this paper emphasizes the value of understanding scientific discovery timetables and the eventual re-discovery in the hands and minds of creative, determined and dedicated scientists, as history tends to repeat itself before its useful application is realized.


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