alexa The Hypolipidemic and Hypoglycemic Activities of Fermented Brown Rice Fibers by Regulating PPARα and ChREBP in the Livers of C57BL/6J Mice
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Hypolipidemic and Hypoglycemic Activities of Fermented Brown Rice Fibers by Regulating PPARα and ChREBP in the Livers of C57BL/6J Mice

Se-Young Kim1,, Jong-Ho Kim1,2,, Yaoyao Jia1, Ji Hae Lee1, Chunyan Wu1, Kwang-Soon Shin3, Byung Serk Hurh2, Yong Ho Choi2and Sung- Joon Lee1*

1Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea

2Sempio Foods Company, 183 Osongsaengmyeong 4ro, Osongeup, Cheongwongun, Chungcheongbukdo 363-954, Korea

3Department of Food Science and Biotechnology, Kyonggi University, Suwon, Gyeonggi-do 443-760, Korea

These authors contribute equally to this study

*Corresponding Author:
Sung-Joon Lee
Department of Biotechnology
Graduate School of Life Sciences and Biotechnology
Korea University, Seoul 136-713, Korea
Tel: +82-2-3290-3029
Fax: +82-2-3290-3653
E-mail: [email protected]

Received date: July 29, 2014; Accepted date: August 25, 2014; Published date: August 29, 2014

Citation: Kim SY, Kim JH, Jia Y, Lee JH, Wu C, et al. (2014) The Hypolipidemic and Hypoglycemic Activities of Fermented Brown Rice Fibers by Regulating PPARa and ChREBP in the Livers of C57BL/6J Mice. J Nutr Food Sci 4: 307 doi: 10.4172/2155-9600.1000307

Copyright: © 2014 Kim SY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The fermentation of brown rice produces black vinegar that has been suggested with beneficial metabolic effects; however, the mechanisms of actions of fermented brown rice have not been studied. We found that fermented brown rice extracts, especially a fraction of fermented brown rice fibers (FBRF), exhibited hypolipidemic and hypoglycemic activities in vivo. The oral administration of FBRF to C57BL/6J mice reduced plasma cholesterol, triglycerides, lowdensity- lipoprotein cholesterol levels, hepatic lipid accumulation and adipocyte size. The activation and induction of hepatic PPARα and subsequent regulation of its target gene expressions in fatty acid uptake and oxidation were the major mechanism for reducing plasma and hepatic triglyceride concentrations. In addition, FBRF improved glucose tolerance and insulin sensitivity. FBRF feeding reduced the expressions of hepatic ChREBP, a key transcription factor in gluconeogenesis, and pro-inflammatory cytokines, thus improved insulin resistance. These results demonstrated that FBR, especially FBRF, shows potent hypolipidemic and anti-diabetic activities through regulating the expression of genes associated with lipid, glucose metabolism and inflammatory cytokines.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version