The IgE-Binding Self-Antigens Tubulin-α and HLA-DR-α are Overexpressed in Lesional Skin of Atopic Eczema Patients
|Claudio Rhyner1*, Sabine Zeller1, Catharina Johansson2, Annika Scheynius2 and Reto Crameri1|
|1Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, CH-7270 Davos, Switzerland|
|2Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institute and Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden|
|Corresponding Author :||Dr. Claudio Rhyner, PhD
Swiss Institute of Allergy and Asthma Research (SIAF)
Obere Strasse 22, CH-7270 Davos Platz, Switzerland
Tel: +41 81 410 08 48
Fax: +41 81 410 08 40
E-mail: [email protected]
|Received January 14, 2011; Accepted April 11, 2011; Published July 20, 2011|
|Citation: Rhyner C, Zeller S, Johansson C, Scheynius A, Crameri R (2011) The Ige-Binding Self-Antigens Tubulin-α and HLA-DR-α are Overexpressed in Lesional Skin of Atopic Eczema Patients. J Clin Cell Immunol 2:109. doi:10.4172/2155-9899.1000109|
|Copyright: © 2011 Rhyner C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: Atopic eczema is the most common chronic, relapsing, inflammatory skin disorder with an atopic background. Previous studies have shown that IgE-mediated reactivity to self-antigens plays a role in the pathogenesis of the disease. However, the expression of self-antigens associated with atopic eczema in the lesional skin is poorly investigated.
Aim of the study: This study was aimed to show that IgE-binding self antigens are over-expressed in atopic eczema lesions. Methods: Tubulin-α and HLA-DR-α, two recently described self-antigens, were stained by immunohistochemistry in skin specimens from chronic and acute atopic eczema lesions, unaffected skin from the same patients or skin from healthy controls.
Results: The expression of tubulin-α and HLA-DR-α is up-regulated in atopic eczema lesions compared to nonlesional or healthy skin and correlates with the number of infiltrating immune cells and the degree of inflammation.
Conclusion: Upregulation of IgE-binding self-antigens in lesional skin of atopic eczema patients might further promote the existing inflammation and induce exacerbations of the disease in the absence of exposure to environmental allergens.