alexa The Impact of Rhinovirus Infections in Paediatric Cardiac Surgery (Risk): Study Protocol for a Prospective Cohort Study | OMICS International
ISSN: 2167-0870

Journal of Clinical Trials
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Protocol

The Impact of Rhinovirus Infections in Paediatric Cardiac Surgery (Risk): Study Protocol for a Prospective Cohort Study

Anneloes L van Rijn1*, Peter P Roeleveld2, Rob BP de Wilde3, Erik W van Zwet4, Mark G Hazekamp5, Jeroen Wink6, Job CJ Calis7, Alois CM Kroes1 and Jutte JC de Vries1
1Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
2Department of paediatric Intensive care, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
3Department of Intensive Care, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
4Department of Statistics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
5Department of thoracic surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
6Department of anaesthesiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
7Department of paediatric Intensive care, Academic Medical Center, Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
Corresponding Author : Anneloes L van Rijn
Department of Medical Microbiology
Leiden University Medical Center
Albinusdreef 2, 2333 ZA Leiden, Netherlands
Tel: +31-(0)71-5263572
Fax: +31-(0)71-5266981
E-mail: [email protected]
Received: October 06, 2015; Accepted: November 25, 2015; Published: December 03, 2015
Citation: van Rijn AL, Roeleveld PP, de Wilde RBP, van Zwet EW, Hazekamp MG, et al. (2015) The Impact of Rhinovirus Infections in Paediatric Cardiac Surgery (Risk): Study Protocol for a Prospective Cohort Study. J Clin Trials 5:246. doi:10.4172/2167-0870.1000246
Copyright: © 2015 van Rijn AL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Respiratory infections are considered a potential risk of adverse events in children undergoing surgery. Rhinovirus is a common cause of respiratory infections and congenital heart disease is a risk factor for severe rhinovirus infection. However, we do not know what the impact of, clinical or subclinical, rhinovirus infections is on postoperative course following congenital heart surgery in children.
Based on our clinical experience, one case-controlled study, and a case reported in the literature, we hypothesize that paediatric patients with per-operative rhinovirus positive Polymerase Chain Reaction testing have a longer paediatric intensive care unit admission, compared to children who test negative.
Methods/Design: This is a prospective single-center observational study in the Leiden University Medical Center with approximately 250 children (<12 years) undergoing elective cardiac surgery, for congenital heart disease.
The parents/guardians of the children will be asked to fill out a questionnaire, to asses respiratory symptoms in the last weeks, before the operation of their child. In the operating theatre, a nasopharyngeal swab will be collected. Clinical data will be collected daily during paediatric intensive care admission and paediatric intensive care unit and hospital length of stay will be recorded. If children are still intubated at day 4, a second nasopharyngeal swab and residual blood will be collected. The samples will be tested for rhinovirus with polymerase chain reaction. Primary outcome is the paediatric intensive care unit length of stay in per-operative rhinovirus-positive compared to rhinovirus-negative patients.
Discussion: This is the first study to screen children for rhinovirus before undergoing cardiac surgery and to study the effects on paediatric intensive care unit length of stay. Furthermore, we aim to identify children at risk for prolonged paediatric intensive care admission after cardiac surgery.

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