alexa The Impact of Serum Interleukin-17 on Chronic Hepatitis C and Its Sequelae
ISSN: 2167-0889

Journal of Liver
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Research Article

The Impact of Serum Interleukin-17 on Chronic Hepatitis C and Its Sequelae

Elham Ahmed Hassan1*, Abeer Sharaf EL-Din Abd El-Rehim1, Asmaa Omar Ahmed2, Nahla Mohamed Elsherbiny3 and Noha Abd El-Rehim Abo Elhagag4
1Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Departments of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
3Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt
4Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
Corresponding Author : Elham Ahmed Hassan
MD, Assiut University Hospital
Tropical Medicine and Gastroenterology
Assiut, Egypt
Tel: +201002963415
Fax: +20882333327
E-mail: [email protected]
Received August 01, 2014; Accepted August 26, 2014; Published September 05, 2014
Citation: Hassan EA, Abd El-Rehim ASE, Ahmed AO, Elsherbiny NM, Abo Elhagag NAE (2014) The Impact of Serum Interleukin-17 on Chronic Hepatitis C and Its Sequelae. J Liver 3:163 doi:10.4172/2167-0889.1000163
Copyright: © 2014 Hassan EA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Recently, interleukin-17 (IL-17) cytokine family plays important roles in the host immunity in chronic inflammatory conditions, autoimmune and viral liver diseases. However, studies on the IL-17 role in the immunopathogenesis of hepatitis C virus (HCV) infection are limited. Objectives: to assess serum IL-17 levels in chronically HCV infected patients and their relations to the severity of liver disease. Patients and methods: The study included 200 chronically HCV infected patients; 100 chronic hepatitis C, 100 liver cirrhosis including 35 with hepatocellular carcinoma (HCC) and 30 controls. Serum IL-17 levels were quantified by ELISA. Results: Serum IL-17 levels were significantly higher in chronically HCV infected patients than controls and cirrhotics had the highest levels (P<0.001). These levels were positively related with inflammation grade and fibrosis stage. Serum IL-17 was significantly higher in HCC than controls. IL-17 was significantly correlated with prothrombin time, ALT, serum albumin, viral load, and alpha fetoprotein-L3. Conclusion: IL-17 levels were increased with increasing liver disease progression and chronicity. Thus, IL-17 may be an important biological marker for the immunopathogenesis of chronic hepatitis, liver fibrosis and HCC.

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