The Impact of Strontium Ranelate on Implant Osseointegration of Osteoporosis in Vivo Experiment
- Corresponding Author:
- Dr. Yuanyuan Zhang
Department of Oral Medicine
Zhengzhou University of School of Stomatology
40 Zhongyuan Road, Zhengzhou, 450052, China
E-mail: [email protected]
Received April 18, 2016; Accepted May 10, 2016; Published May 18, 2016
Citation: Wang M, Liu Q, Yang C, Zhang Y (2016) The Impact of Strontium Ranelate on Implant Osseointegration of Osteoporosis in Vivo Experiment. Dentistry 6:376. doi:10.4172/2161-1122.1000376
Copyright: ©2016 Wang M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To investigate the impact of strontium ranelate on implant osseointergration of osteoporotic rats in vivo experiment.
Method: Thirty-six female rats were randomly divided into three groups: ovariectomization group (A=12), strontium ranelate low-dose treatment group (B=12) and strontium ranelate high-dose treatment group (C=12). After the success of the osteoporosis model building, HA coated titanium implants were inserted into proximal metaphyses of tibiae, meanwhile, the rats of group B and C received oral medication of strontium ranelate (B: 450 mg/kg.d C: 900 mg/kg.d), 12 weeks after surgery, animals were killed and decalcified sections were prepared and examined histologically and histomorphometrically, as well as micro-CT examination.
Results: 12 weeks after implantation surgery, bone mineral density (BMD), implant bone contact rate (IBCR) and new bone volume (NBV) in group B and C were significantly higher compared with group A (p<0.01).
Conclusion: Strontium ranelate may resist the negative influence of osteoporosis and promote osseointergration of implant.