alexa The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Review Article

The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis

Thomas R Cox and Janine T Erler*

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej, 5, Copenhagen 2200, Denmark

*Corresponding Author:
Janine T. Erler
Biotech Research and Innovation Centre (BRIC)
University of Copenhagen
Ole Maaløes Vej, 5
Copenhagen 2200, Denmark
E-mail: [email protected]

Received Date: March 05, 2013; Accepted Date: April 20, 2013; Published Date: April 30, 2013

Citation: Cox TR, Erler JT (2013) The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis. J Carcinogene Mutagene S13:001. doi: 10.4172/2157-2518.S13-001

Copyright: © 2013 Cox TR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The Extracellular Matrix (ECM) presents a fundamentally important local microenvironment for cancer cells in terms of tumour development and progression. A major component of the ECM is the diverse and complex collection of macromolecules, which come together to provide the biochemical and biomechanical cues responsible for controlling individual and collective cell behaviour. Under normal conditions, the tight control of ECM composition and regulation of ECM dynamics (remodelling) is critical to correct organ development and homeostasis.

Dysregulation of these normal ECM dynamics plays an enormous role in diseases such as cancer by disrupting normal cell behaviour. Understanding how changes in ECM remodelling drive cancer is critical to developing efficacious therapies targeting the tumour ECM. In this mini review we focus on the Lysyl Oxidase (LOX) family of proteins and their importance in post-translational modification of ECM components in the context of tumourigenesis.

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