The Important Roles of C4d in Systemic Lupus Erythematosus
Juan Li and Zhuoli Zhang*
Rheumatology and Clinical Immunology Department, Peking University First Hospital, Beijing, China
- *Corresponding Author:
- Zhuoli Zhang, MD, PhD
Director, Rheumatology and Clinical Immunology Department
Peking University First Hospital, Address: No.8
Xishiku Street West District, Beijing, 100034, China
E-mail: [email protected]
Received Mar 24, 2014; Accepted Jun 25, 2014; Published Jun 30, 2014
Citation: Li, Zhang (2014) The Important Roles of C4d in Systemic Lupus Erythematosus. Rheumatology (Sunnyvale) 4:135. doi: 10.4172/2161-1149.1000135
Copyright: © 2014 Li J T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of various autoantibodies and the injury of multiple systems. It is well known that the complement system plays an important role in the pathogenesis of SLE. Complement activation product C4d is a marker of the classical complement activation and hence can be used to reflect the tissue injury as well as therapeutic effects. Besides its important role in antibody-mediated rejection, C4d has been increasingly recognized as a potential biomarker in SLE. Here we will summarize the recent advances of C4d in SLE.