alexa The Influence of Clinical Staging and Use of Antiretroviral Therapy on Cognitive Functioning of School-Aged Nigerian Children with HIV Infection | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Influence of Clinical Staging and Use of Antiretroviral Therapy on Cognitive Functioning of School-Aged Nigerian Children with HIV Infection

Gbemisola O Boyede1,2*, Foluso E A Lesi2, Veronica C Ezeaka2 and Charles S Umeh3

1Division of Developmental Paediatrics, School and Child and Adolescent Health, Red Cross War Memorial Children’s Hospital, University of Cape Town, Cape Town, South Africa

2Department of Paediatrics, College of Medicine, University of Lagos, Nigeria

3Clinical Psychology Unit, Department of Psychiatry, Lagos University Teaching Hospital, Lagos, Nigeria

*Corresponding Author:
Gbemisola O Boyede
Division of Developmental Paediatrics
School and Child and Adolescent Health
Red Cross War Memorial Children’s Hospital
University of Cape Town, Cape Town, South Africa
Tel: +27791150729
E-mail: [email protected]

Received Date: January 25, 2013; Accepted Date: February 26, 2013; Published Date: March 03, 2013

Citation: Boyede GO, Lesi FEA, Ezeaka V, Umeh CS (2013) The Influence of Clinical Staging and Use of Antiretroviral Therapy on Cognitive Functioning of School-Aged Nigerian Children with HIV Infection. J AIDS Clin Res 4:195. doi:10.4172/2155-6113.1000195

Copyright: © 2013 Boyede GO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To find out how the World Health Organization Clinical Stages of HIV infection and use of antiretroviral therapy influence cognitive functioning of school-aged HIV-infected Nigerian children.

Method: Cognitive assessments of 69 HIV positive children aged 6–15 years were performed using Raven’s Standard Progressive Matrices. Thirty children were on Highly Active Antiretroviral Therapy. The children were subdivided for the purpose of analysis into two cognitive developmental stages using Piaget’s developmental stage: the concrete operation stage (6–11 years) and the formal operation stage (12–15 years). Children on antiretroviral therapies were also compared with those not on therapies. HIV infection was staged using the revised World Health Organization Clinical Staging for Paediatric HIV/AIDS.

Result: The overall mean cognitive score for HIV positive subjects on antiretroviral therapy was 20.9 which was significantly higher than the overall score for subjects not on therapies of 14.6 (p=0.007). In the age group 6–11 years, the mean cognitive scores became lower significantly with worsening clinical stage for subjects irrespective of use of anti-retroviral therapy. The mean scores for subjects on therapy were significantly higher than that of their counterparts not yet on therapy at the same clinical stage. There were no significant differences in the cognitive scores at different clinical stages among the children in the age group 12–15 years.

Conclusion: Cognitive scores were lower with worsening clinical staging in the younger school-aged HIV-infected Nigerian children. Subjects on Highly Active Anti-retroviral Therapy had better cognitive scores than subjects not on therapy at the same clinical stage. Routine neuropsychological evaluation for school-aged HIV-infected children are recommended with an emphasiss on the younger children.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7