alexa The Influence of GSTA1 Polymorphism to the Response to Intravenous Cyclophosphamide Therapy in the Lupus Nephritis Patients

Lupus: Open Access

  • Short Communication   
  • Lupus Open Access 2016, Vol 1(2): 115

The Influence of GSTA1 Polymorphism to the Response to Intravenous Cyclophosphamide Therapy in the Lupus Nephritis Patients

Hong-Na Wang1, Xiao-Ye Zhu2, Ying Zhu2, Miao Zhao3, Yuan-Cheng Chen3, Jun Xue2*, Chuan-Ming Hao2, Yong Gu2 and Shan-Yan Lin2
1Department of Nephrology, Haihe Hospital, 890 Jingu Road, Tianjin 300350, PR China
2Department of Nephrology, Huashan Hospital, Fudan University, 12 middle Wulumuqi Road, Shanghai 200040, PR China
3Institute of Antibiotics, Huashan Hospital, Fudan University, 12 middle Wulumuqi Road, Shanghai 200040, PR China
*Corresponding Author: Jun Xue, Department of Nephrology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, PR China, Tel: 86-21-52887797, Email: [email protected]

Received Date: Mar 23, 2016 / Accepted Date: Apr 25, 2016 / Published Date: Apr 29, 2016

Abstract

Variations of clinical response of cyclophosphamide (CTX) treatment in lupus nephritis (LN) could still be recognized. LN patients with a GSTA1mutation (CT heterozygous) had a risk of none-response (P=0.005). Pharmacokinetics data indicated that patients with a GSTA1 heterozygous variant had a lower exposure to 4-OHCTX compared to wild-type patients (P=0.023). And clinical efficacy was significantly related to higher exposure to 4- OH-CTX (P=0.038). In conclusion, LN patients with GSTA1 heterozygousgenotypes had poor CTX treatment response due to less exposure to activated 4-OH-CTX.

Keywords: Lupus nephritis; Nephrology; Cyclophosphamide; GSTA1; Pharmacokinetics; Pharmacogenomics

Citation: Wang NH, Zhu XY, Zhu Y, Zhao M, Chen YC, et al. (2016) The Influence of GSTA1 Polymorphism to the Response to Intravenous Cyclophosphamide Therapy in the Lupus Nephritis Patients. Lupus Open Access 1: 115.

Copyright: © 2016 Wang HN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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