The Influence of Polymorphisms in the MxA Promoter and the elF-2α Regulatory Region 2 on the Natural outcome of HBV InfectionXin-su Wei1 , Ping-an Zhang1 *, Fang-li Ye1 , Yan Li1 , Bing Deng2
- *Corresponding Author:
- Ping-an Zhang
Department of Laboratory Science
Renmin Hospital of Wuhan University
Received date: February 24, 2012; Accepted date: April 24, 2012; Published date:April 29, 2012
Citation: Wei X S, Zhang PA, Ye FL, Li Y, Deng B (2012) The Influence of Polymorphisms in the MxA Promoter and the elF-2a Regulatory Region 2 on the Natural outcome of HBV Infection. Hereditary Genet 1:106. doi: 10.4172/2161-1041.1000106
Copyright: © 2012 Wei X S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Interferon(IFN) stimulates the expression of a number of genes encoding enzymes with antiviral activities, including myxovirus resistance A(MxA) and double-stranded RNA-dependent protein kinase(PKR). PKR is also activated by dsRNA, this leads to the phosphorylation of eukaryotic initiation factor 2a(elF-2α), which halts viral replication. We investigated whether polymorphisms in MxA promoter and elF-2α regulatory region 2(elF-2α reg2) influenced the natural outcome of hepatitis B virus(HBV) infection. A total of 243 patients with chronic HBV infection and 160 patients with self-limited HBV infection were used to genotype and identify this single-nucleotide polymorphism(SNP) by polymerase chain reaction-restriction fragment length polymorphism and sequencing, respectively. The distribution of the genotypes(GG, GT, and TT) at position -88 in the MxA promoter was 52.7%, 44.4%, and 2.9% in patients with chronic HBV infection and 41.3%, 43.1%, and 15.6% in patients with self-limited HBV infection, respectively. The frequencies of the TT genotype at position -88 in the MxA promoter were significantly higher among patients with self-limited HBV infection compared with patients with chronic HBV infection (odds ratio=6.24; 95% CI: 2.63-14.81; P=0.001). However, the polymorphisms both at position -123 in the MxA promoter and in the elF-2α reg2 were not significantly different between the two groups (P>0.05). In conclusion, Polymorphism at position -88G/T in the MxA promoter influences the natural outcomes of HBV infection to some extent. This SNP of MxA promoter may be used as a clinical prognostic marker of HBV infection.