alexa The Influence of Silver Nanoparticles on the Blood-Brai
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

Sandra Cramer1, Sebastian Tacke2, Julia Bornhorst3, Jürgen Klingauf2, Tanja Schwerdtle3 and Hans-Joachim Galla1*

1Institute of Biochemistry, University of Münster, Wilhelm-Klemm-Straße 2, D-48149 Münster, Germany

2Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Str. 31, D-48149 Münster, Germany

3Institute of Nutritional Sciences, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany

*Corresponding Author:
Hans-Joachim Galla
Institute of Nutritional Sciences
University of Potsdam, Arthur-Scheunert-Allee 114-116
14558 Nuthetal, Germany
Tel: 49-251-8333205
E-mail: [email protected]

Received Date: July 25, 2014; Accepted Date: August 23, 2014; Published Date: August 27, 2014

Citation: Cramer S, Tacke S, Bornhorst J, Klingauf J, Schwerdtle T, et al. (2014) The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro. J Nanomed Nanotechnol 5:225. doi:10.4172/2157-7439.1000225

Copyright: © 2014 Cramer S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The use of silver nanoparticles in medical and consumer products such as wound dressings, clothing and cosmetic has increased significantly in recent years. Still, the influence of these particles on our health and especially on our brain, has not been examined adequately up to now. We studied the influence of AgEO- (Ethylene Oxide) and AgCitrate-Nanoparticles (NPs) on the protective barriers of the brain, namely the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (blood-CSF) barrier in vitro. The NPs toxicity was evaluated by examining changes in membrane integrity, cell morphology, barrier properties, oxidative stress and inflammatory reactions. AgNPs decreased cell viability, disturbed barrier integrity and tight junctions and triggered oxidative stress and DNA strand breaks. However, all mentioned effects were, at least partly, suppressed by a Citrate-coating and were most pronounced in the cells of the BBB as compared to the epithelial cells representing the blood-CSF barrier. AgEO- but not AgCitrate-NPs also triggered an inflammatory reaction in porcine brain capillary endothelial cells (PBCEC), which represent the BBB. Our data indicate that AgNPs may cause adverse effects within the barriers of the brain, but their toxicity can be reduced by choosing an appropriate coating material.


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