The Integral Plasmodium Life Cycle Phenomenon: Gametocyte GenesVineeta Singh* and Amit Kumar
National Institute of Malaria Research (ICMR), Sector-8, Dwarka, New Delhi 110077, India
- *Corresponding Author:
- Vineeta Singh
Cell Biology Laboratory and Malaria Parasite Bank
National Institute of Malaria Research (ICMR)
Sector-8, Dwarka, New Delhi 110077, India
E-mail: [email protected]
Received date: February 13, 2015; Accepted date: April 21, 2015; Published date: April 27, 2015
Citation: Vineeta Singh, Amit Kumar (2015) The Integral Plasmodium Life Cycle Phenomenon: Gametocyte Genes. J Bacteriol Parasitol 6:224. doi: 10.4172/2155-9597.1000224
Copyright: © 2015 Vineeta Singh, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Gametocytes are the sexual stages of the Plasmodium species. The transmission of parasite relies on these gametocytes which are the crucial link in its life cycle. The biology of parasitic life cycle is complex with the invasion of host red blood cells (RBCs) by merozoites after the pre-erythrocytic invasion and followed with erythrocytic invasions and multiplications. This review examines the involvement of gametocyte-specific genes in gametocytogenesis. Here we look at the six gametocyte specific genes- Pfs16, Pfs25, Pfg27, Pfs48/45, Pfs230 and Pfg377; their developmental commitment, gene expression causing cellular and molecular changes in sexual differentiation. The in depth understanding of the gametocytogenesis in the transition from asexual to sexual differentiation could help to develop new strategies to curtail effectively the malaria transmission.