alexa The Interplay between the Androgen Receptor, Soluble Factors and Tumour Microenvironment
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
Open Access

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Review Article

The Interplay between the Androgen Receptor, Soluble Factors and Tumour Microenvironment

Vikash Reebye1, Jeri Kim2, Andrea Frilling1, Joanna P. Nicholls1, Nagy A. Habib1 and Paul J. Mintz1*

1Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12, 0NN, UK

2Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Unit 1374, 1515 Holcombe Blvd, Houston, TX 77030, USA

Corresponding Author:
Dr. Paul J. Mintz
Department of Surgery and Cancer
Faculty of Medicine, Imperial College London
London, W12 0NN, UK
E-mail: [email protected]

Received Date: August 20, 2011; Accepted Date: October 20, 2011; Published Date: October 24, 2011

Citation: Reebye V, Kim J, Frilling A, Nicholls JP, Habib NA, et al. (2011) The Interplay between the Androgen Receptor, Soluble Factors and Tumour Microenvironment. J Steroids Hormon Sci S2:002. doi: 10.4172/2157-7536.S2-002

Copyright: © 2011 Reebye V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 Maintaining a balanced prostate microenvironment is pivotal for normal development and homeostasis of the prostate gland. This balance however is severely disrupted during the progression of prostate cancer where the local microenvironment becomes compromised. The cellular components associated with the microenvironment, including stromal cells, immune cells, blood vessels, and the extracellular matrix, interact cooperatively with prostate cancer cells through paracrine and autocrine actions of soluble growth factors and cytokines thus creating a modified tumour microenvironment. Understanding how paracrine and autocrine factors interact in this microenvironment may lead to improved understanding of prostate cancer progression and to the development of drug combinations that might target both the primary and metastatic prostate cancer tumour microenvironments.

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