The Leptin to Adiponectin Ratio is a Marker of the Number of Metabolic Syndrome Criteria in French Adults
|A Gauthier1, S Dubois1, S Bertrais2, Y Gallois3, C Aube4, F Gagnadoux5, P Cales2, V Rohmer1, G Leftheriotis6, PH Ducluzeau1*|
|1Département de diabétologie-nutrition, CHU Angers, 4 rue Larrey, Angers, F-49033 France|
|2Laboratoire HIFIH, UPRES 3859, IFR 132, Université d’Angers, F-49033 France|
|3Département de biologie, CHU Angers, 4 rue Larrey, Angers, F-49033 France|
|4Département de radiologie, CHU Angers, 4 rue Larrey, Angers, F-49033 France|
|5Département de pneumologie, CHU Angers, 4 rue Larrey, Angers, F-49033 France|
|6Département d’exploration fonctionnelle vasculaire, CHU Angers, 4 rue Larrey, Angers, F-49033 France|
|Corresponding Author :||Dr. PH Ducluzeau
Département de diabétologie-nutrition
CHU Angers, 4 rue Larrey
Angers, F-49033 France
Tel: +33 241 35 44 97
Fax: +33 241 35 59 00
E-mail: [email protected]
|Received October 25, 2011; Accepted December 15, 2011; Published December 31, 2011|
|Citation: Gauthier A, Dubois S, Bertrais S, Gallois Y, Aube C, et al. (2012) The Leptin to Adiponectin Ratio is a Marker of the Number of Metabolic Syndrome Criteria in French Adults. J Metabolic Synd 1:101. doi:10.4172/2167-0943.1000101|
|Copyright: © 2012 Gauthier A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aim: Visceral distribution of adipose tissue (AT) is one of the key components of Metabolic Syndrome (MetS). Plasma concentrations of leptin and adiponectin are closely linked to AT distribution. Pulse wave velocity (PWV), a marker of arterial stiffness, is linked to metabolic syndrome and cardiovascular risk. The purpose of this study is to describe the extent of the usefulness of the Leptin/Adiponectin (L/A) ratio as a marker of MetS.
Methods: Leptin and adiponectin concentrations, magnetic resonance image-based of visceral and subcutaneous fat measurements, and carotid PWV were analyzed in the subjects of a French prospective cohort composed of 97 subjects not presenting metabolic syndrome (MetS-), 122 patients with metabolic syndrome (MetS+) without diabetes, and 94 type 2 diabetics (T2D) with MetS.
Results: After adjustment for gender and age, leptinemia was found to be higher in MetS+ patients than in T2D patients. Adiponectinemia alone was not discriminated. There was a statistically significant difference in the L/A ratio between MetS- patients and the other groups. For the whole population, there is a positive correlation between the L/A and waist circumference, waist-to-hip ratio, visceral fat (r=0.53), triglyceride concentrations, fasting glucose concentrations, insulinemia, systolic and diastolic blood pressure, and number of MetS criteria (r=0.39). The L/A ratio is also significantly correlated with carotid artery stiffness.
Conclusion: This study demonstrates the potential usefulness of the L/A ratio as a marker, independent of age and gender, of a subject’s metabolic risk. The L/A Ratio is also a reliable marker for arterial stiffness.