alexa The Level of Natural Anticoagulants in Transfusion Dependent Thalassemia Patients in Kelantan, Northeastern Malaysia | OMICS International | Abstract
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Research Article

The Level of Natural Anticoagulants in Transfusion Dependent Thalassemia Patients in Kelantan, Northeastern Malaysia

Rosnah B*, Noor Halina MN, Shafini Y, Marini R, Rosline H, Amal Hayati H
School of Medical Sciences, Universiti Sains Malaysia Kubang Kerian, Kelantan, Malaysia
Corresponding Author : Rosnah Bte Bahar, MD
MPath (Haemato) Senior Lecturer and Haematologist Hematology Department
Health Campus, Universiti Sains Malaysia
16150 Kubang Kerian,Kelantan, Malaysia
Tel: 60179444492
Fax: +6097652709
Office: +6097676190
Email: [email protected]
Received March 11, 2014; Accepted May 1, 2014; Published May 7, 2014
Citation: Rosnah B, Noor Halina MN, Shafini Y, Marini R, Rosline H et al. (2014) The Level of Natural Anticoagulants in Transfusion Dependent Thalassemia Patients in Kelantan, Northeastern Malaysia. J Hematol Thrombo Dis 2:140. doi:10.4172/2329-8790.1000140
Copyright: © 2014 Rosnah B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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Abstract

The association of the severe form of thalassemia with complications of blood transfusion, iron overload, bony deformity and gall stone is well described. Currently, due to improvement in the way of managing thalassemia, most of thalassemia patients survive longer. However more new complications had been observed. Increased incidence of thromboembolism among thalassemia patients had triggered various studies done to determine hypercoagulable state among thalassemia patients. Several factors for the hypercoagulable state had been identified such as RBC membrane disruption, chronic platelet activation and defect in coagulation pathway. This study was carried out to determine the level of Protein C, protein S, free protein S and antithrombin among thalassemia patients and to compare the level of Protein C, protein S, free Protein S and antithrombin level between thalassemia patients and healthy control. This was a case control study done at Hospital Universiti Sains Malaysia. Thirty six thalassemia patients who came for regular blood transfusion and 20 healthy blood donors for normal control were recruited. Blood samples were collected and analyzed for Protein C, protein S, free protein S and antithrombin using ACL Elite Pro. The result showed mean Protein C and free protein S levels were significantly lower (54.8 ± 13.2% and 70.0 ± 12.1% respectively) in thalassemia patients compared to age-matched normal control (94.1 ± 16.3% and 99.8 ± 17.3% respectively), whereas mean total protein S (54.8 ± 13.2% and 94.1 ± 16.3%; respectively) and antithrombin (70.0 ± 12.1% and 99.8 ± 17.3%; respectively) level were similar. In conclusion there was a significantly decreased Protein C and free protein S in thalassemia patients which might suggests hypercoagulable state in thalassemia patients. Since there are a lot of similarities in finding from other studies, we believe that many more study to look for other parameters contributing to hypercoagulable state in thalassemia patients is needed.

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