alexa The Link between Uncontrolled Asthma and Sensitization to Inhalant Allergens: Evidence from Jeddah, Saudi Arabia
ISSN: 2327-4972

Family Medicine & Medical Science Research
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Research Article

The Link between Uncontrolled Asthma and Sensitization to Inhalant Allergens: Evidence from Jeddah, Saudi Arabia

Majdy M Qutub1*, Emad A Koshak1 and Moufag M Tayeb2
1Department of Internal medicine, allergy and clinical immunology, Faculty of Medicine, King Abdulaziz University, Saudi Arabia
2Faculty of Medicine, King Abdulaziz University, Saudi Arabia
Corresponding Author : Qutub MM
Imperial College London, Faculty of Medicine
King Abdulaziz University, P.O Box 53281
Jeddah 21583, Saudi Arabia
Tel: 00966-505629047
Fax: 00966-126224205
E-mail: [email protected]
Received: October 22, 2015; Accepted: December 05, 2015; Published: December 14, 2015
Citation: Qutub MM, Koshak EA, Tayeb MM (2015) The Link between Uncontrolled Asthma and Sensitization to Inhalant Allergens: Evidence from Jeddah, Saudi Arabia. Fam Med Med Sci Res 5:191. doi:10.4172/2327-4972.1000191
Copyright: © 2015 Qutub MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: For optimal asthma control, current guidelines recommend the assessment of allergy phenotype. This study investigates the relationship between asthma control and sensitization to inhalant allergens.

Methods: A cross-sectional study was conducted over a one year period since January 2011. Asthmatics were sequentially selected from allergy clinic at King Abdulaziz University Hospital in Jeddah. Evaluation of asthma control was based on GINA guideline. Assessment of the sensitization towards inhalant allergens was measured in-vivo by wheal size and number of positive reactions on the standard skin prick test (SPT). SPSS was used to analyse any statistical correlation.

Results: A total of 110 asthmatics with a mean age of 34 ± 14 years were included, 63.6% being females. Asthma was predominantly uncontrolled in 68 cases (61.8%), partly controlled in 26 cases (23.6%) and controlled in 16 cases (14.5%). SPT to common inhalant allergens was positive in 76 asthmatics (77.6%); of which 54 (55.1%) were uncontrolled, 13 (13.3%) partly controlled and only 9 (9.2%) were controlled asthmatics. The predominant allergens were Dermatophagoides pteronyssinus in 57 cases (54.8%), Dermatophagoides farinae in 49 cases (47.1%), cat epithelia in 35 cases (33.7%) and cockroach in 23 cases (22.1%). Uncontrolled asthma was correlated significantly with positive SPT (p=0.038).

Conclusions: More than half of the uncontrolled asthmatics population is sensitized to indoor inhalant allergens. This clinically favours the assessment of allergic status in any asthmatic, whose symptoms are not controlled. This is one of the early studies exploring the potential link between asthma control and sensitization to inhalant allergens.

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