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ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Review Article

The Long Pentraxin PTX3: A Biomarker Spanning From Cardiovascular Disorders to Cancer

Marco Falasca1*, Fabrizia Bonacina2, Alberico Luigi Catapano2,3 and Giuseppe Danilo Norata1,2,4*

1Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, UK

2Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy

3IRCCS Multimedica, Italy

4Center for the Study of Atherosclerosis, Società Italiana Studio Aterosclerosi, Ospedale Bassini, Italy

*Corresponding Author:
Marco Falasca
Blizard Institute, Queen Mary University of London
4 Newark Street, E1 2AT London, UK
Tel: +44 20 78828243
Fax: +44 20 78822186
E-mail: [email protected]

Giuseppe Danilo Norata
Department of Pharmacological and Biomolecular Sciences
University of Milan, Via Balzaretti 9, 20133, Milan, Italy
Tel: +39 02 50318313
Fax: +39 02 50318386
E-mail: [email protected]

Received date: July 26, 2013; Accepted date: August 16, 2013; Published date: August 19, 2013

Citation: Falasca M, Bonacina F, Catapano AL, Norata GD (2013) The Long Pentraxin PTX3: A Biomarker Spanning From Cardiovascular Disorders to Cancer. J Mol Biomark Diagn 4:146. doi:10.4172/2155-9929.1000146

Copyright: © 2013 Falasca M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Inflammatory mediators may play key roles in both atherosclerosis and cardiovascular disorders and in cancer development. Pentraxins are a family of proteins characterized by the structural motif pentraxin domain. Long pentraxin 3 (PTX3), a protein that in humans is encoded by the PTX3 gene, is rapidly produced and released by several cell types in response to inflammatory stimuli. This review discusses the evidence supporting the role of PTX3 in predicting primary cardiovascular events and diagnosis and prognosis of cancer.

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