alexa The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review

Ryan Mokhtari1 and Herbert M Lachman1,2,3,4*

1Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, USA

2Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, USA

3Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, USA

4Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, USA

Corresponding Author:
Herbert M. Lachman
Department of Psychiatry and Behavioral Sciences
Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, USA
Tel: 718-430-2428
E-mail: [email protected]

Received Date: November 11, 2016; Accepted Date: December 14, 2016; Published Date: December 21, 2016

Citation: Mokhtari R, Lachman HM (2016) The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review. J Clin Cell Immunol 7:479. doi:10.4172/2155-9899.1000479

Copyright: © 2016 Mokhtari R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Epidemiological studies and mouse models suggest that maternal immune activation, induced clinically through prenatal exposure to one of several infectious diseases, is a risk factor in the development of schizophrenia. This is supported by the strong genetic association established by genome wide association studies (GWAS) between the human leukocyte antigen (HLA) locus and schizophrenia. HLA proteins (also known in mice as the major histocompatibility complex; MHC) are mediators of the T-lymphocyte responses, and genetic variability is wellestablished as a risk factor for autoimmune diseases and susceptibility to infectious diseases. Taken together, the findings strongly suggest that schizophrenia risk in a subgroup of patients is caused by an infectious disease, and/or an autoimmune phenomenon. However, this view may be overly simplistic. First, MHC proteins have a non-immune effect on synaptogenesis by modulating synaptic pruning by microglia and other mechanisms, suggesting that genetic variability could be compromising this physiological process. Second, some GWAS signals in the HLA locus map near non-HLA genes, such as the histone gene cluster. On the other hand, recent GWAS data show association signals near B-lymphocyte enhancers, which lend support for an infectious disease etiology. Thus, although the genetic findings implicating the HLA locus are very robust, how genetic variability in this region leads to schizophrenia remains to be elucidated.


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