alexa The Mathematical Aspects of our Published Cooperative Specificity Theory: The Entropy Change, (ΔS), Potentiates Protein – Protein Interaction
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

The Mathematical Aspects of our Published Cooperative Specificity Theory: The Entropy Change, (ΔS), Potentiates Protein – Protein Interaction

Norbert O Temajo*

Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia

*Corresponding Author:
Norbert O. Temajo
Institute of Endocrinology and Diabete
The Children’s Hospital at Westmead
15 Gould St, Turner, ACT 2612, Australia
Tel: +61 2 62627619
Fax: +61 2 98453170
E-mail: [email protected]

Received date: May 06, 2014; Accepted date: June 01, 2014; Published date: June 06, 2014

Citation: Temajo NO (2014) The Mathematical Aspects of our Published Cooperative Specificity Theory: The Entropy Change, (ΔS), Potentiates Protein – Protein Interaction. J Diabetes Metab 5:384 doi: 10.4172/2155-6156.1000384

Copyright: © 2014 Temajo NO. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The Co-operative Specificity Theory explains the reciprocal recognition between specific MHC DR/DQ molecules in a haplotype resulting in a co-operation that precipitates susceptibility to T1D. Co-operativity between protein molecules is the probable formation of one H-bond which seduces the formation of a greater number of H-bonds leading to a strong association between the two molecules. In co-operative specificity the binding between positively and negatively charged aa residues on the specific DR- and DQ-molecules occurs in a procedure that is rapid, exact and in an all-or-none fashion resulting in only one achieved maximal extremum. We theorize that protein molecules in the proteome sense each other’s level of entropy ΔS in search of partner parity, with lowest ΔS existing between two molecules spelling co-operativity with resulting expansion of ΔS.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]csonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords