alexa The Mathematical Aspects of our Published Cooperative S
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Review Article

The Mathematical Aspects of our Published Cooperative Specificity Theory: The Entropy Change, (ΔS), Potentiates Protein – Protein Interaction

Norbert O Temajo*

Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia

*Corresponding Author:
Norbert O. Temajo
Institute of Endocrinology and Diabete
The Children’s Hospital at Westmead
15 Gould St, Turner, ACT 2612, Australia
Tel: +61 2 62627619
Fax: +61 2 98453170
E-mail: [email protected]

Received date: May 06, 2014; Accepted date: June 01, 2014; Published date: June 06, 2014

Citation: Temajo NO (2014) The Mathematical Aspects of our Published Cooperative Specificity Theory: The Entropy Change, (ΔS), Potentiates Protein – Protein Interaction. J Diabetes Metab 5:384 doi: 10.4172/2155-6156.1000384

Copyright: © 2014 Temajo NO. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The Co-operative Specificity Theory explains the reciprocal recognition between specific MHC DR/DQ molecules in a haplotype resulting in a co-operation that precipitates susceptibility to T1D. Co-operativity between protein molecules is the probable formation of one H-bond which seduces the formation of a greater number of H-bonds leading to a strong association between the two molecules. In co-operative specificity the binding between positively and negatively charged aa residues on the specific DR- and DQ-molecules occurs in a procedure that is rapid, exact and in an all-or-none fashion resulting in only one achieved maximal extremum. We theorize that protein molecules in the proteome sense each other’s level of entropy ΔS in search of partner parity, with lowest ΔS existing between two molecules spelling co-operativity with resulting expansion of ΔS.


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