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ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Review Article

The Molecular Alterations Regarding Apoptosis in Hepatocellular Carcinoma Cells at a Glance

Yi Yuan1#, Yu Sheng Zhang2# and Xian-Jun Qu1*

1Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China

2Department of Science and Technology, Shandong University, Ji’nan 250012, China

#These authors contributed equally to this work

*Corresponding Author:
Dr. Xian-Jun Qu
School of Pharmaceutical Sciences
Shandong University, No. 44, Wen Hua Xi Road
Ji'nan 250012, China
Tel/Fax:+86-531-88382490
E-mail: [email protected]

Received date: Janurary 20, 2011; Accepted date: March 01, 2011; Published date: March 04, 2011

Citation: Yuan Y, Zhang YS, Qu XJ (2011) The Molecular Alterations Regarding Apoptosis in Hepatocellular Carcinoma Cells at a Glance. J Carcinogene Mutagene 2:118. doi: 10.4172/2157-2518.1000118

Copyright: © 2011 Yuan Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ranking one of the most critical worldwide health troubles relating to mortality, hepatocellular carcinoma (HCC) has been a grievous scourge of humanity for a long time. Despite that plentiful attempts have been made, it still remains being a great challenge for us to conquer this disease. Multiple molecular alterations can be frequently detected in the pathogenesis and development of HCC, such as members of Ras family, Bcl-2 family and tumor suppressors. Importantly, most of these alterations are responsible for disrupting the balance between cell proliferation and apoptosis, which has been generally voted as a key event closely associated with carcinogenesis. Hence, this review aims to update the current related articles and provide a further understanding about such molecular changes relevant to trigger imbalances in the regulation of apoptosis in HCC.

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