alexa The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome | OMICS International | Abstract
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
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Research Article

The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome

Ming-Shan Kao1, Yanhan Wang2, Shinta Marito1, Stephen Huang3, Wan-Zhen Lin1, Jon A Gangoiti4, Bruce A Barshop4, Choi Hyun4, Woan-Ruah Lee5, James A Sanford2, Richard L Gallo2, Yuping Ran6, Wan-Tzu Chen7, Chun-Jen Huang8, Ming-Fa Hsieh7* and Chun-Ming Huang2,9*

1Department of Life Sciences, National Central University, Taoyuan, Taiwan

2Department of Dermatology, University of California, San Diego, CA, USA

3Surface Bioadvances Inc., San Diego, CA, USA

4Department of Pediatrics University of California, San Diego, CA, USA

5Department of Dermatology, Taipei Medical University, Taipei, Taiwan

6Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China

7Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan

8Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan

9Moores Cancer Center; University of California, San Diego, CA, USA

*Corresponding Authors:
Chun-Ming Huang
Department of Dermatology
University of California, San Diego, CA, USA
Tel: 858-822-4627
E-mail: [email protected]
Ming-Fa Hsieh
Department of Biomedical Engineering
Chung Yuan Christian University, Taoyuan, Taiwan
Tel: +886 3 265 9999
E-mail: [email protected]

Received date: May 12, 2016; Accepted date: June 09, 2016; Published date: June 19, 2016

Citation: Kao MS, Wang Y, Marito S, Huang S, Lin WZ, et al. (2016) The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome. J Microb Biochem Technol 8:259-265. doi:10.4172/1948-5948.1000295

Copyright: © 2016 Kao MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes. Our probiotic approaches using a selective fermentation initiator of skin commensal bacteria, fermentation metabolites or their derivatives provide novel therapeutics to rein in the over-growth of fungi. Staphylococcus lugdunensis (S. lugdunensis) bacteria and Candida parapsilosis (C. parapsilosis) fungi coexist in the scalp microbiome. S. lugdunensis interfered with the growth of C. parapsilosis via fermentation. A methoxy poly(ethylene glycol)-b-poly(ɛ-caprolactone) (mPEG-PCL) copolymer functioned as a selective fermentation initiator of S. lugdunensis, selectively triggering the S. lugdunensis fermentation to produce acetic and isovaleric acids. The acetic acid and its pro-drug diethyleneglycol diacetate (Ac-DEG-Ac) effectively suppressed the growth of C. parapsilosis in vitro and impeded the fungal expansion in the human dandruff. We demonstrate for the first time that S. lugdunensis is a skin probiotic bacterium that can exploit mPEG-PCL to yield fungicidal short-chain fatty acids (SCFAs). The concept of bacterial fermentation as a part of skin immunity to re-balance the dysbiotic microbiome warrants a novel avenue for studying the probiotic function of the skin microbiome in promoting health.

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