The Multifaceted Biological Roles of Vitamin CShiu-Ming Kuo*
Department of Exercise and Nutrition Sciences and Department of Biochemistry, University at Buffalo, Buffalo, NY 14214, USA
- *Corresponding Author:
- Shiu-Ming Kuo
Department of Exercise and Nutrition Sciences and Department of Biochemistry
University at Buffalo, Buffalo, NY 14214, USA
E-mail: [email protected]
Received date: August 19, 2013; Accepted date: September 21, 2013; Published date: September 23, 2013
Citation: Kuo SM (2013) The Multifaceted Biological Roles of Vitamin C. J Nutr Food Sci 3:231. doi:10.4172/2155-9600.1000231
Copyright: © 2013 Kuo SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Scurvy due to severe vitamin C (ascorbic acid) deficiency among sailors was one of the earliest documented occupational diseases. This review first discussed some reduction potential-based biochemical activities of vitamin C such as assisting the post-translational collagen modification as well as acting as an antioxidant and pro-oxidant. These known activities of vitamin C were then used to address recent outcomes of vitamin C clinical trials on the prevention and treatment of non-scurvy diseases such as cardiovascular diseases and cancer. The pro-oxidant activity may contribute to the adverse effect of high-level vitamin C supplementation in clinical trials.