alexa The Neuropathogenesis of Acanthamoeba encephalitis: Barriers to Overcome
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Research Article

The Neuropathogenesis of Acanthamoeba encephalitis: Barriers to Overcome

Naveed Ahmed Khan* and Ruqaiyyah Siddiqui
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
Corresponding Author : Naveed Ahmed Khan
Department of Biological and Biomedical Sciences
Aga Khan University, Stadium Road, Karachi, Pakistan
Tel: 92-(0)21-3486-4540
Fax: 92-(0)21-3493-4294
E-mail: [email protected]
Received August 30, 2011; Accepted October 07, 2011; Published October 09, 2011
Citation: Ahmed Khan N, Siddiqui R (2011) The Neuropathogenesis of Acanthamoeba encephalitis: Barriers to Overcome. J Cell Sci Ther S3:001. doi: 10.4172/2157-7013.S3-001
Copyright: © 2011 Ahmed Khan N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Acanthamoeba encephalitis exhibits broad spectrum of neuropathology depending on the localization of the lesions. Natural infection is associated with haematogenous spread leading to Acanthamoeba entry into the brain, most likely via the blood-brain barrier, although blood-cerebrospinal fluid barrier has also been suggested as a possible route. Experimental infection is induced by intranasal injection of parasites, followed by amoebae invasion of the central nervous system via the olfactory neuroepithelium route. The precise mechanism of entry and the factors that influence amoebae entry into the central nervous system are not fully understood. The development of strategies to combat this fatal infection requires an understanding of the interactions between Acanthamoeba and the central nervous system.

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