alexa The Neutrophil Extracellular Traps: The Missed Link bet
ISSN: 2153-0769

Metabolomics:Open Access
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Review Article

The Neutrophil Extracellular Traps: The Missed Link between Microvascular Inflammation and Diabetes?

Berezin A*

Internal Medicine Department, State Medical University for Zaporozhye, 26, Mayakovsky Av., Zaporozhye, 69035, Ukraine

*Corresponding Author:
Berezin A, Professor, PhD
Consultant of Therapeutic Unit
Internal Medicine Department
State Medical University for Zaporozhye
26, Mayakovsky Av., Zaporozhye
Postcode 69035, Ukraine
Tel.: +38 061 2894585
Fax: +38 0612894585
E-mail: [email protected]

Received Date: October 30, 2015; Accepted Date: January 21, 2016; Published Date: January 23, 2016

Citation: Berezin A (2016) The Neutrophil Extracellular Traps: The Missed Link between Microvascular Inflammation and Diabetes? Metabolomics 6:163.doi: 10.4172/2153-0769.1000163

Copyright: © 2016 Berezin A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Microvascular inflammation is considered as a trigger for vasculopathy and early atherosclerosis development in diabetes mellitus. However, activated mononuclears/macrophages/neutrophils play a pivotal role in pathogenesis of vascular complications among individuals with diabetes mellitus. The neutrophil extracellular traps (NETs) have been known as a component of innate immune system for the last few decades. NETosis is induced by pathogens as well as other stimuli such as activated platelets, metabolic triggers, and oxidative stress components. In diabetes, neutrophils are primed to release NETs and die by NETosis. The objective of the mini review is to highlight the possible role of NETosis in early diabetes-related vasculopathy beyond cardiovascular complications.

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