alexa The Occurrence of HIV-1 Resistance Biomarker Among Two Cohorts from Poland

Journal of Molecular Biomarkers & Diagnosis
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Research Article

The Occurrence of HIV-1 Resistance Biomarker Among Two Cohorts from Poland

Aleksandra Siekierzynska1,2*, Aleksander Myszka1,2, Ryszard Slezak3, Izabela Laczmanska3 and Maciej Wnuk1,2

1Department of Genetics, University of Rzeszow, 35-959 Rzeszow, Poland

2Centre of Applied Biotechnology and Basic Sciences, University of Rzeszow, 36-100 Kolbuszowa, Poland

3Department of Genetics, Wroclaw Medical University, 50-368 Wroclaw, Poland

*Corresponding Author:
Aleksandra Siekierzynska
Department of Genetics, University of Rzeszow
35-959 Rzeszow, Poland
E-mail: [email protected]

Received Date: May 30, 2011; Accepted Date: June 20, 2011; Published Date: June 27, 2011

Citation: Siekierzynska A, Myszka A, Slezak R, Laczmanska I, Wnuk M (2011) The Occurrence of HIV-1 Resistance Biomarker Among Two Cohorts from Poland. J Mol Biomark Diagn 2:108. doi:10.4172/2155-9929.1000108

Copyright: © 2011 Siekierzynska A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Approximately 1% of the Caucasians shows resistance to HIV-1 infection conditioned by 32bp deletion in CCR5 gene. Homozygotes are almost totally resistant, but heterozygotes have delay the progression to AIDS. Due to the constantly increase of HIV infection in Poland we examined the incidence of del32 allele in two cohorts (south-western and south-eastern region of country) that remarkably differs in the incidence of HIV. Among the individuals from the south-western region, we detected 7 homozygotes (2.6%), in compare with individuals from the south-eastern area of Poland, where we found 1 homozygote (0.4%). The prevalence of CCR5del32 allele in the group from the southwestern region was estimated at 11.6%, while in the group from the south-eastern region was assessed at 9.7%. Differences in the prevalence of genotypes and alleles between regions were not statistically significant. Our results were discussed in relation to the incidence of HIV infection in Poland. We conclude that occurence of CCR5del32 biomarker does not reflect the incidence of HIV in the examined regions.

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