alexa The Outcome of Surgery in Patients with Growth Hormone Secreting Adenomas: Early Surgical Sntervention is Essential for improving the Surgical Cure Rate
ISSN: 2167-0943

Journal of Metabolic Syndrome
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Outcome of Surgery in Patients with Growth Hormone Secreting Adenomas: Early Surgical Sntervention is Essential for improving the Surgical Cure Rate

Hidetoshi Ikeda1*, Shunsuke Sato1, Toshiyuki Saginoya2, Takamasa Kudo1,3 and Kazuo Watanabe4
1Research Institute for Pituitary Diseases, Southern Tohoku General Hospital, Koriyama, Fukushima, Japan
2Department of Radiology, Southern Tohoku General Hospital, Koriyama, Fukushima, Japan
3Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
4Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama, Fukushima, Japan
Corresponding Author : Hidetoshi Ikeda, M.D. Ph.D.
7-115 Yatsuyamada
Research Institute for Pituitary Diseases
Southern Tohoku General Hospital
Koriyama, Fukushima 963-8563, Japan
Tel: +81-24-934-5322
Fax: +81-24-922-5320
E-mail: [email protected]
Received September 12, 2012; Accepted September 27, 2012; Published September 29, 2012
Citation: Ikeda H, Sato S, Saginoya T, Kudo T, Watanabe K (2012) The Outcome of Surgery in Patients with Growth Hormone Secreting Adenomas: Early Surgical Intervention is Essential for Improving the Surgical Cure Rate. J Metabolic Synd S2:001. doi:10.4172/2167-0943.S2-001
Copyright: © 2012 Ikeda H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Object: During the last 10 years, 129 consecutive transsphenoidal operations for growth hormone (GH) secreting pituitary adenomas have been carried out. In the present study, 120 of the patients involved in these operations have been reviewed to evaluate the accuracy of diagnosis of adenoma, the cure rate, and to ascertain the favorable surgical effects of early surgical intervention.

Methods: A total of 120 GH secreting adenomas, including 95 patients with typical acromegaly and 25 patients with no apparent clinical features of acromegaly, were evaluated. The pituitary tumors were investigated by means of Magnetic Resonance (MR) imaging at 1.5T and 3T, composite 3T-MRI and [11C] Methionine-positron Emission Tomography (MET-PET) imaging and histological and immunohistochemical staining. The modern remission criteria (a glucose suppressed [nadir] GH level of less than 1.0 ng/ml, a random GH level of 2.5 ng/ml or less, and a normal sex and age adjusted insulin-like growth factor-1 [IGF-1] level) were used. To assess remission we examined these criteria at 1, 6 and 12 months after surgery.

Results: The diagnostic accuracy of 3T-MRI and composite MET-PET fusion 3T- MRI in localizing adenoma was 87 and 100%, respectively. The mean age of patients with pre-clinical acromegaly and acromegaly was 37.3 and 51.1 years, respectively. The mean preoperative GH levels in these patients were 4.85 and 34.7 ng/ml for preclinical acromegaly and acromegaly, respectively. The mean preoperative IGF-1 levels for pre-clinical acromegaly and acromegaly were 323 and 822 ng/ml, respectively. The mean volume of the adenoma in patients with pre-clinical acromegaly and acromegaly were 1.26 and 3.84 cm3, respectively. There was a significant difference (P <0.0001) between the pre-clinical acromegaly and acromegaly groups in terms of age, GH and IGF-1 levels, and tumor volume. The overall cure rate for growth hormone-secreting adenoma was 73% using modern criteria; the surgical cure rate for acromegaly patients was 65%, while the surgical cure rate for patients without obvious clinical features of acromegaly was 100%. Patients with pre-clinical acromegaly had a tendency to have smaller sized adenomas, a younger age, lower GH and IGF-1 levels, and a better surgical cure rate relative to patients with typical acromegaly. No complications such as carotid artery injury, hypothalamic injury, cerebrospinal fluid fistula or permanent diabetes insipidus occurred. Only one acromegaly patient had hypopituitarism after surgery.

Conclusions: Early detection of GH secreting adenoma is important since early surgical intervention can achieve a 100% cure rate without serious complications.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version