alexa The Ovarian Innervation Participates in the Regulation
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

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Review Article

The Ovarian Innervation Participates in the Regulation of Ovarian Functions

Roberto Domínguez1* and Sara E. Cruz-Morales2

1Faculty of gradúate studies, Research Unit In Reproductive Biology, Zaragoza College of Professional Studies, National Autonomous University of Mexico, Mexico

2Faculty of gradúate studies Iztacala, National Autonomous University of Mexico, Mexico

corresponding Author:
Roberto Domínguez
Research Unit In Reproductive Biology
Zaragoza College of Professional Studies
National Autonomous University of Mexico, Mexico
E-mail: [email protected]

Received Date: August 29, 2011; Accepted Date: October 14, 2011; Published Date: October 19, 2011

Citation: Domínguez R, Cruz-Morales SE (2011) The Ovarian Innervation Participates in the Regulation of Ovarian Functions. Endocrinol Metabol Syndrome S4:001. doi: 10.4172/2161-1017.S4-001

Copyright: © 2011 Domínguez R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The release of gonadotropins is the main endocrine signal regulating ovulation and the release of hormones by the
ovaries. Several types of growth factors modulate the effects of gonadotropins on the follicular, luteal and interstitial
compartments of the ovaries. During the last 30 years, numerous studies have indicated that the ovarian innervations
play a role in modulating the effects that gonadotropin have on the ovaries’ ability to ovulate and secrete steroid
hormones. This literature review presents a summary of the experimental results obtained by analyzing the effects
of stimulating or blocking the well-known neural pathways participating in the regulation of ovulation and secretion
of steroid hormones. Together, the results suggest that various neurotransmitter systems modulate the effects of
gonadotropins on ovulation and the ovaries capacity to secrete steroid hormones. In addition, the ovaries asymmetric
capacity for ovulation and hormone secretion could be explained by the asymmetries in their innervations.

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