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The Pathogenesis of Lupus Nephritis | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

The Pathogenesis of Lupus Nephritis

Rosalie M. Sterner1,2, Stella P. Hartono1,2 and Joseph P. Grande1*
1 Department of Laboratory Medicine & Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA
2 Medical Scientist Training Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA
Corresponding Author : Joseph P. Grande, M.D., Ph.D
Mayo Clinic, 200 First Street SW
Rochester MN 55905 USA
Tel: 1-507-266-9356
Fax: 1-507-266-1163
Email: [email protected]
Received February 28, 2014; Accepted April 02, 2014; Published April 09, 2014
Citation: Sterner RM, Hartono SP, Grande JP (2014) The Pathogenesis of Lupus Nephritis. J Clin Cell Immunol 5:204. doi:10.4172/2155-9899.1000205
Copyright: © 2014 Sterner RM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Lupus nephritis is a serious potential feature of systemic lupus erythematous (SLE). Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage. This review of the pathogenesis of lupus nephritis examines the role of the complement cascade; the significance of autoantibodies, the breaking of tolerance, and the implications of altered apoptosis in breaking tolerance; and the contributions of adaptive immunity and cross-talk with the innate immune system in driving renal damage. Delineation of basic mechanisms underlying the development of acute and chronic renal damage in lupus nephritis can result in the continued development of more specific and effective treatments.

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