The Pharmacokinetic Study of Aspirin, Paracetamol and Naproxen with Magnesium Sulfate
Shah Amran1*, Sabiha Ferdowsy Koly1, Sangita Paul Kundu1, Abu Asad Chowdhury1, Amjad Hossain1, Zakir Sultan2, Asma Rahman2, Sagar Kumar Paul3, Satabdi Shikder3, Tasneem Nayla Mredula3and Shampa Kundu4
- *Corresponding Author:
- Md. Shah Amran
Professor, Department of Pharmaceutical
Chemistry Faculty of Pharmacy
University of Dhaka, Dhaka-1000
E-mail: [email protected]
Received date: December 08, 2015; Accepted date: May 15, 2015; Published date: May 22, 2015
Citation: Amran S, Koly SF, Kundu SP, Chowdhury AA, Hossain A, et al. (2015) The Pharmacokinetic Study of Aspirin, Paracetamol and Naproxen with Magnesium Sulfate. Pharm Anal Acta 6:372. doi: 10.4172/2153-2435.1000372
Copyright: ©2015 Amran S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study was designed to evaluate the bioavailability of single drug as well as drug with Mg(II) complexes in the systemic circulation of rats. 132 healthy rats were selected for this study. The rats were fasted for 12 hours (overnight) prior to drug administration and kept fasting up to blood collection after administration of the drugs. The rats were divided in to three groups for each drug of study: control (rats without giving any drugs for each analysis) and group 1 for reference (single drug) and group 2 for test drug i.e. drug-Mg complexes. In this study both the test (drug-Mg complex) drug and corresponding reference drug were administered at the dose of aspirin at 10 mg/kg body weight, paracetamol at 16 mg/kg body weight and naproxen at 16 mg/kg body weight in the solution form through oral route. From the pharmacokinetic study, it was found that concomitant administration of magnesium with aspirin slightly increased elimination rate and lowered the bioavailability than the reference aspirin. When magnesiun was concomitantly administered with paracetamol, it markedly increased elimination rate and decreased the bioavailability than that of the reference paracetamol. When magnesiun was concomitantly administered with naproxen, it decreased elimination rate and remained in the systemic circulation for longer time.