The Plasmalemmal Na/K-ATPase: An Amplifier for Reactive Oxygen Species?
Kyle D Maxwell, Preeya T Shah and Joseph I Shapiro*
The Department of Medicine, The Joan C. Edwards School of Medicine of Marshall University, USA
- *Corresponding Author:
- Joseph I Shapiro
Dean, Joan C. Edwards School of Medicine
Professor of Medicine, Marshall University
1600 Medical Center Drive
Huntington, WV 25701-3655, USA
Tel: 304 691 1700
Fax: 304 691 1726
E-mail: [email protected]
Received Date: December 30, 2014; Accepted Date: January 27, 2015; Published Date: February 05, 2015
Citation: Kyle D Maxwell, Preeya T Shah, Joseph I Shapiro (2015) The Plasmalemmal Na/K-ATPase: An Amplifier for Reactive Oxygen Species?. J Hypertens 4:197. doi:10.4172/2167-1095.1000197
Copyright: © 2015 Shapiro JI. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although the plasmalemmal sodium potassium adenosine triphosphatase (Na/K-ATPase) is one of the most studied proteins in Biology or Medicine, a signaling function believed to be independent of its pumping function has only been noted in the past 20 years. This signaling function appears to require the generation of reactive oxygen species (ROS) which, in turn requires the activation of Src and the transactivation of the epithelial growth factor receptor (EGFR). Recent data suggest that the Na/K-ATPase may also serve as a receptor for some ROS and in this manner, serve to amplify oxidant signaling. The mechanisms involved and the implications for Physiology and Medicine are discussed in this review.