alexa The Polymorphisms rs2516839 of USF1 and -173G/C of MIF were not Associated with Coronary Artery Disease but Dyslipidemia in a Chinese Population
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
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Research Article

The Polymorphisms rs2516839 of USF1 and -173G/C of MIF were not Associated with Coronary Artery Disease but Dyslipidemia in a Chinese Population

Chaoneng Wu1,2#, Yunguo Gong1,2#, Xiao Zhu3, Jie Yuan1,2, Aijun Sun1,2, Yunzeng Zou1,2* and Junbo Ge1,2*
1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
2Institute of Biomedical Science, Fudan University, China
3Guangdong Province Key Laboratory of Medical Molecular Diagnosis, Guangdong Medical College, Dongguan, China
#These authors contributed equally to the research
Corresponding Author : Junbo Ge
Shanghai Institute of Cardiovascular Diseases
Zhongshan Hospital, Fudan University
180 Feng Lin Road, Shanghai 200032, China
Tel: 86-21-64041990
Fax: 86-21-6422 3006
E-mail: [email protected]
  Yunzeng Zou
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital
Fudan University, 180 Feng Lin Road, Shanghai 200032, China
Tel: 86-21-64041990
Fax: 86-21-6422 3006 E-mail: [email protected]
Received August 05, 2014; Accepted September 29, 2014; Published October 06, 2014
Citation: Wu C, Gong Y, Zhu X, Sun A, Yuan J, et al. (2014) The Polymorphisms rs2516839 of USF1 and -173G/C of MIF were not Associated with Coronary Artery Disease but Dyslipidemia in a Chinese Population. J Cardiovasc Dis Diagn 2:177. doi: 10.4172/2329-9517.1000177
Copyright: © 2014 Wu C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Objective: The genome-wide association studies have pointed out lots of disease-associated variants in coronary artery disease (CAD). However, whether the polymorphisms of rs2516839 of upstream transcription factor (USF1) and -173G/C (rs755622) of macrophage migration inhibitory factor (MIF) are associated with CAD has remained undetermined. This study was to explore the associations between these two polymorphisms and the risk of CAD and dyslipidemia. Methods: A case-control study was carried out in 654 angiographic confirmed CAD patients and 455 none-CAD control subjects. The polymorphisms were detected by TaqMan SNP Genotyping Assays. Results: We did not observe significant association between the polymorphism of rs2516839 of USF1 with CAD risk, neither -173G/C (rs755622) of MIF. In the subgroup analysis of myocardial infarction and hypertension, the associations for theses two polymorphisms were negative also. However, the GG genotype carriers of rs2516839 of USF1 showed significantly lower levels of cholesterol, low-density lipoprotein cholesterol and apolipoprotein B. Conclusions: Our findings showed that the rs2516839 of USF1 and -173G/C (rs755622) of MIF do not contribute to CAD risk. Nevertheless, the rs2516839 of USF1 might have a protection for the dyslipidemia disorders.

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