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The Potential Clinical Implications of Telomerase Reverse Transcriptase in the Detection and Diagnosis of Bladder Cancer | OMICS International | Abstract
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

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Review Article

The Potential Clinical Implications of Telomerase Reverse Transcriptase in the Detection and Diagnosis of Bladder Cancer

Yitian Wang1, Bo Wang1, Meng Zhang1, Zhiming Cai1* and Song Wu1,2*

1Shenzhen Second People's Hospital, clinical medicine college of Anhui Medical University, Shenzhen Guangdong, China

2Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou Guangdong, China

*Corresponding Author:
Song Wu
Shenzhen Second People's Hospital
clinical medicine college of Anhui Medical University
Shenzhen Guangdong, China
Tel: +0086010075583669030
Fax: +0086010075583669030
E-mail: [email protected]

Zhiming Cai
Shenzhen Second People's Hospital
clinical medicine college of Anhui Medical University
Shenzhen Guangdong, China
Tel: +0086010075583669030
Fax: +0086010075583669030
E-mail: [email protected]

Received date April 21, 2014; Accepted date: June 25, 2014; Published date: June 27, 2014

Citation: Wang Y, Wang B, Zhang M, Cai Z, Wu S (2014) The Potential Clinical Implications of Telomerase Reverse Transcriptase in the Detection and Diagnosis of Bladder Cancer. Hereditary Genet 3:131. doi: 10.4172/2161-1041.1000131

Copyright: © 2014 Wang Y et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Telomerase and the control of telomere length are intimately linked to the process of tumorigenesis in humans and mutations in the promoter regions of its catalytic subunit, TERT, can affect telomerase activity and telomere, creating severe clinical phenotypes. In this paper, we briefly review the potential mechanisms under which TERT play in tumorigenesis and focus mainly on TERT’s potential as a biomarker for the detection and diagnosis of bladder cancer.

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