alexa The Potential of Intralesional Rose Bengal to Stimulate
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses

Ajay V Maker1,2*, Bellur Prabhakar2 and Krunal Pardiwala1
1Division of Surgical Oncology, Department of Surgery, University of Illinois at Chicago, Chicago Illinois, USA
2Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago Illinois, USA
Corresponding Author : Ajay V Maker, MD, FACS
Division of Surgical Oncology
Department of Surgery
University of Illinois at Chicago
Chicago Illinois, USA
Tel: 773-296-7379
E-mail: [email protected]
Received: April 23, 2015 Accepted: July 15, 2015 Published: July 22, 2015
Citation: Maker AV, Prabhakar B, Pardiwala K (2015) The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses. J Clin Cell Immunol 6:343. doi:10.4172/2155-9899.1000343
Copyright: © 2015 Maker AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Rose Bengal (RB) is a red synthetic dye that was initially used in the garment industry and has been used safely for decades as a corneal stain by ophthalmologists. Antineoplastic properties of RB have also been observed, though the mechanism of action remained to be elucidated. Recently, interest in RB as a therapeutic cancer treatment has increased due to significant anti-tumor responses with direct tumor injection in human clinical trials for metastatic melanoma. In these patients, there has been the implication that RB may mount a T-cell mediated antitumor response and impart antigen-specific responses in distant bystander lesions. This article serves to evaluate the potential of intralesional rose bengal to stimulate T-cell mediated anti-tumor responses in in-vitro, pre-clinical, and clinical studies.

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