alexa The Potential of Neospora caninum Immunogens against Neosporosis
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Potential of Neospora caninum Immunogens against Neosporosis

Piraine REA1 , Silva RAE2*, Junior AGDS3, Cunha RC4 and Leite FPL5

1Programa de Pós Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico (CDTec), Universidade Federal de Pelotas, Pelotas, RS, Brasil

2Laboratório de Biologia Molecular do Carrapato, Embrapa Gado de Corte (CNPGC), Campo Grande, MS, Brasil

3Programa de Pós Graduação em Veterinária, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brasil

4Programa de Pós Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico (CDTec), Universidade Federal de Pelotas, Pelotas, RS, Brasil

5Laboratório de Microbiologia, Departamento de Biotecnologia, Centro de Desenvolvimento Tecnológico (CDTec), Universidade Federal de Pelotas, Pelotas, RS, Brasil

*Corresponding Author:
Silva RAE
Zona Rural, Campo Grande
MS, Brasil
Tel: +55673368-2173
Fax: +55673368-2150
E-mail: [email protected]

Received date: September 30, 2015; Accepted date: November 17, 2015; Published date: November 20, 2015

Citation: Piraine REA, Silva RAE, Junior AGDS, Cunha RC, Leite FPL (2015) The Potential of Neospora caninum Immunogens against Neosporosis. J Vaccines Vaccin 6:298. doi: 10.4172/2157-7560.1000298

Copyright: © Silva RAE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Neospora caninum, the parasite that causes neosporosis, is known worldwide as one of the main drivers of abortion in cattle herds, causing economic losses when raising livestock. Parasitic infection and transmission among animals is difficult to combat, and both diagnostics and controls must be applied to reduce the spread of the pathogen. For control, herd vaccinations represent an alternative, but the current lack of a safe and effective vaccine prevents this method. The parasite has a significant array of structural proteins that assist in the process of infection; surface antigens (SAGs), microneme proteins (MICs), dense granule antigens (GRAs) and rhoptria proteins (ROPs). Antigens from these proteins are currently being studied as immunogens; they are tested alone or in associations, in order to evaluate the induced immune response in animal models. In experimental vaccine studies, different approaches are used in the formulations, such as live vaccines, DNA vaccines, vaccines using biological vectors, and recombinant subunit vaccines (usually developed with the aid of reverse vaccinology). The contrasts observed (in both cytokine levels and protection rates against vertical transmission), in vaccinated and then challenged (N. caninum), laboratory animals show the complexity of parasite invasion mechanisms, and reveal the need for further research to isolate an effective vaccine to protect cattle against the parasite.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords