alexa The Potential of Tissue Engineering and Regeneration for Craniofacial Bone
ISSN: 2161-1122

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Review Article

The Potential of Tissue Engineering and Regeneration for Craniofacial Bone

Seiichi Yamano1*, Ken Haku1, Mika Ishioka1, Terry Y. Lin1, Shigeru Hanatani1, Jisen Dai1 and Amr M. Moursi2

1Department of Prosthodontics, New York University College of Dentistry, New York, NY, USA

2Department of Pediatric Dentistry, New York University College of Dentistry, New York, NY, USA

*Corresponding Author:
Seiichi Yamano
Department of Prosthodontics, New York University College of Dentistry
345 East 24th Street
4W, New York, NY 10010, USA
Tel: 212-998-9714
Fax: 212-992-7100
E-mail: [email protected]

Received date: March 15, 2012; Accepted date: May 15, 2012; Published date: May 21, 2012

Citation: Yamano S, Haku K, Ishioka M, Lin TY, Hanatani S, et al. (2012) The Potential of Tissue Engineering and Regeneration for Craniofacial Bone. Dentistry 2:136. doi: 10.4172/2161-1122.1000136

Copyright: © 2012 Yamano S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Bone regeneration is a complex, well-coordinated physiological process. Large quantities of bone regeneration are often required for craniofacial skeletal reconstruction of large bone defects created by trauma, tumor resection, infection, and skeletal abnormalities. Over the last two decades, a tissue engineering and regeneration approach has been developed as an alternative to conventional surgical treatments using bone grafts. Tissue engineering methods have several advantages including the potential to regenerate bone with natural form and function. This review presents several key elements of tissue engineering for craniofacial bone: the signaling molecules (proteins and genes); scaffolds or supporting matrices; and cells. Furthermore, the advantages, challenges, and risks related with each element will be discussed.


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