alexa The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis
ISSN: 2161-1149

Rheumatology: Current Research
Open Access

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Review Article

The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis

Charles A Kallick Rush*

University Medical Center, Department of Medicine, 1825 W, Harrison, Chicago, IL 60612, USA

*Corresponding Author:
Charles A Kallick Rush
University Medical Center, Department of Medicine
1825 W, Harrison, Chicago, IL 60612, USA
Tel: 206-783-0986
E-mail: [email protected]

Received date: November 07, 2013; Accepted date: December 26, 2013; Published date: January 25, 2014

Citation: Kallick Rush CA (2014) The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis. Rheumatology 4:128. doi: 10.4172/2161-1149.1000128

Copyright: © 2014 Kallick Rush CA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In a study of autoimmune disease (AD), a hemotropic bacterial agent, Ehrlichia/Anaplasma (EA) is suggested as
associated or possibly etiologic. These bacteria are obligate intracellular parasites with demonstrated ability to disrupt
transcription in the rapidly dividing bone marrow cell. Two papers have definitively placed this agent in systemic
lupus erythematosus (SLE). Bacterial structures resembling endosomes have been shown to be present in bone
marrow megakaryocytes when using phase contrast microscopy. Marrow cells construct lymphocytes using fragments
of DNA of body tissue; 60% are self-reactive, but are eliminated before release to the circulation. EA have been
shown to alter transcription of infected cells and alteration of DNA during transcription can explain many of the factors
involved in AD. PCR of a Patient with demonstrated infection of 2% parasitized erythrocytes with EA, revealed a
single gene of the major surface protein2 (MSP2), which aligned within 97% of the single gene from an animal EA,
Anaplasma phagocytophillium transmitted to man by ticks. EA has limited antibiotic susceptibility, and is sensitive only
to rifamycins, tetracyclines, and quinolones. Confirmation of the presence of EA in whole blood examined of patients
with AD using the techniques reported here, especially molecular methods to find a bacterium which is very difficult to
culture may enlarge the treatment, and research options available to immunologist-rheumatologists.

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