The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and PathogenesisCharles A Kallick Rush*
University Medical Center, Department of Medicine, 1825 W, Harrison, Chicago, IL 60612, USA
- *Corresponding Author:
- Charles A Kallick Rush
University Medical Center, Department of Medicine
1825 W, Harrison, Chicago, IL 60612, USA
E-mail: [email protected]
Received date: November 07, 2013; Accepted date: December 26, 2013; Published date: January 25, 2014
Citation: Kallick Rush CA (2014) The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis. Rheumatology 4:128. doi: 10.4172/2161-1149.1000128
Copyright: © 2014 Kallick Rush CA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Methotrexate is a Disease Modifying Anti Rheumatic Drug (DMARD) we used in the treatment of patients with severe fibromyalgia symptoms. We present two case discussions of low dose methotrexate treatment resulting in dramatic relief of widespread body pain in patients diagnosed with fibromyalgia. These patients had been refractory to prior treatment with opioids, NSAIDs, anti-seizure medications, anti-depressant medications, pregabalin and corticosteroids. Our case reports endorse Sota Omoigui’s theory of pain which states that the origin of all pain is inflammation and the inflammatory response. Low dose methotrexate has unique broad spectrum anti-inflammatory activity that is not found in any other medication. The drug may significantly decrease or resolve generalized body pain associated with fibromyalgia. The use of low dose Methotrexate co-administered with folic acid should be considered as an adjunct to pain medication to help decrease and sometimes eliminate pain and improve other symptoms such as fatigue and disability in fibromyalgia. Limiting factors include the ability of patients to tolerate the medication.