alexa The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis
ISSN: 2161-1149

Rheumatology: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis

Charles A Kallick Rush*

University Medical Center, Department of Medicine, 1825 W, Harrison, Chicago, IL 60612, USA

*Corresponding Author:
Charles A Kallick Rush
University Medical Center, Department of Medicine
1825 W, Harrison, Chicago, IL 60612, USA
Tel: 206-783-0986
E-mail: [email protected]

Received date: November 07, 2013; Accepted date: December 26, 2013; Published date: January 25, 2014

Citation: Kallick Rush CA (2014) The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis. Rheumatology 4:128. doi: 10.4172/2161-1149.1000128

Copyright: © 2014 Kallick Rush CA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In a study of autoimmune disease (AD), a hemotropic bacterial agent, Ehrlichia/Anaplasma (EA) is suggested as
associated or possibly etiologic. These bacteria are obligate intracellular parasites with demonstrated ability to disrupt
transcription in the rapidly dividing bone marrow cell. Two papers have definitively placed this agent in systemic
lupus erythematosus (SLE). Bacterial structures resembling endosomes have been shown to be present in bone
marrow megakaryocytes when using phase contrast microscopy. Marrow cells construct lymphocytes using fragments
of DNA of body tissue; 60% are self-reactive, but are eliminated before release to the circulation. EA have been
shown to alter transcription of infected cells and alteration of DNA during transcription can explain many of the factors
involved in AD. PCR of a Patient with demonstrated infection of 2% parasitized erythrocytes with EA, revealed a
single gene of the major surface protein2 (MSP2), which aligned within 97% of the single gene from an animal EA,
Anaplasma phagocytophillium transmitted to man by ticks. EA has limited antibiotic susceptibility, and is sensitive only
to rifamycins, tetracyclines, and quinolones. Confirmation of the presence of EA in whole blood examined of patients
with AD using the techniques reported here, especially molecular methods to find a bacterium which is very difficult to
culture may enlarge the treatment, and research options available to immunologist-rheumatologists.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version