alexa The Potential Role of Hydroxy Methylbutyrate (HMB) in t
ISSN: 2329-6607

Cardiovascular Pharmacology: Open Access
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The Potential Role of Hydroxy Methylbutyrate (HMB) in the Management of Lean Body Mass Loss in Older Adults with Heart Failure and Cardiac Cachexia

Peter A McCullough1,2, Christina B Berberich3, Carolyn Alish3 and Refaat A Hegazi3*

1Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas, USA

2The Heart Hospital, Plano, Texas, USA

3Scientific and Medical Affairs, Abbott Nutrition (Abbott Laboratories), Columbus, Ohio, USA

Corresponding Author:
Refaat A Hegazi
Scientific and Medical Affairs
Abbott Nutrition (Abbott Laboratories)
Columbus, Ohio, USA
Tel: 724-234-8336
E-mail: [email protected]

Received Date: October 10, 2015; Accepted Date: October 29, 2015; Published Date: November 05, 2015

Citation: McCullough PA, Berberich CB, Alish C, Hegazi RA (2015) The Potential Role of β−Hydroxy−β−Methylbutyrate (HMB) in the Management of Lean Body Mass Loss in Older Adults with Heart Failure and Cardiac Cachexia. Cardiovasc Pharm Open Access 4:161. doi:10.4172/2329-6607.1000161

Copyright: © 2015 McCullough PA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The loss of muscle mass and strength is a consequence of the aging process and can occur during periods of bed rest, inactivity, trauma, illness as well. For older adults with advanced heart failure (HF)- associated cachexia, disease-related loss of muscle mass and strength is a complication of the disease state and is associated with deconditioning and frailty. As patients with HF progress, the likelihood of developing malnutrition and cachexia increases. Cachexia is associated with lean body mass (LBM) loss and is correlated with a worsening prognosis in HF. Nutrition interventions beyond simple caloric replacement could be an important adjuvant therapy for a better clinical outcome. Specifically, nutrients that improve the muscle protein synthesis and decrease degradation are of special consideration for the management of cardiac cachexia. Dietary protein intake, oral nutrition supplements and β-hydroxy β- methylbutyrate (HMB) are few examples. HMB is the active metabolite of the essential amino acid leucine and is found in trace amounts in some foods. It has been shown to inhibit muscle proteolysis and modulate protein turnover. It is also been shown to stabilize muscle cell walls through the production of cholesterol within the muscle tissue. In the following review, we will focus on HMB as a potential nutritional compound that could help address the HF-associated loss of LBM and its consequences.

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