The Prevalence of Non-alcoholic Fatty Liver Disease and its Association with Metabolic Syndrome and Obesity in Pediatric Population of North India
|Irshad Ahmad Parry1, Riyaz Ahmad Bhat1*, Showkat Ali Zargar2, Ashraf Ganie3 and Imran Khan1|
|1Department of Internal Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India|
|2Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India|
|3Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India|
|Corresponding Author :||Dr. Riyaz Ahmad Bhat
Department of Internal Medicine
Sher-i-Kashmir Institute of Medical Sciences
Srinagar, Kashmir, India
E-mail: [email protected]
|Received December 01, 2012; Accepted January 23, 2013; Published January 25, 2013|
|Citation: Parry IA, Bhat RA, Zargar SA, Ganie A, Khan I (2012) The Prevalence of Non-alcoholic Fatty Liver Disease and its Association with Metabolic Syndrome and Obesity in Pediatric Population of North India. J Metabolic Synd 1:118. doi:10.4172/2167-0943.1000118|
|Copyright: © 2012 Parry IA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: This study was conducted to evaluate the prevalence of fatty liver and its associations with the components of metabolic syndrome in school children of Kashmir valley of north India.
Methods: In this cross-sectional study, a total of 1112 children aged 4-18 years were selected from different schools of Kashmir valley. Anthropometric assessments, blood pressure measurements and fasting blood samples were obtained after proper consent. Ultrasonography was performed by a single sonologist on prefixed dates. Fatty liver was defined by already established criteria for fatty liver disease. Metabolic syndrome was defined according to Adult treatment panel III criteria. Analysis and inferences were drawn using Student’s test, chi-square test, Man Whitney U test and logistic regression analysis.
Results: The overall prevalence of fatty liver was 7.4%. The Prevalence of fatty liver in children with metabolic syndrome was 44.4%% and in obese children it was 61%. Body Mass Index, waist circumference and metabolic syndrome are strongly correlated with the prevalence of fatty liver.
Conclusion: This study is the first study from India on the prevalence of fatty liver disease in children. The estimates of our study are unexpectedly high and immediate attention is needed to address the problem.