The Prevention of Gestational DiabetesEmilio Giugliano1*, Elisa Cagnazzo1, Brunella Giugliano1, Donatella Caserta2, Massimo Moscarini2 and Roberto Marci1
- *Corresponding Author:
- Emilio Giugliano
Department of Morphology, Surgery and Experimental Medicine
Section of Obstetrics and Gynecology, University of Ferrara
CorsoGiovecca 203, Ferrara, Italy 44121
E-mail: [email protected]
Received date: July 24, 2013; Accepted date: August 21, 2013; Published date: August 26, 2013
Citation: Giugliano E, Cagnazzo E, Giugliano B, Caserta D, Moscarini M, et al. (2013) The Prevention of Gestational Diabetes. J Diabetes Metab 4:286. doi: 10.4172/2155-6156.1000286
Copyright: © 2013 Giugliano E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The negative impact of the gestational diabetes on the maternal and fetal health is well known and this impact is closely related to gestational age at which the diagnosis is done. Therefore, the use of therapeutic options able to prevent or delay the gestational diabetes occurrence has a positive impact on maternal and neonatal outcomes.
Physical activity and dietary advice represent the first choice and they are the most studied as well. They represent a non-pharmacological option and have a positive impact on insulin resistance although they do not seem to prevent the gestational diabetes onset.The preconceptional use of metformin in women with polycystic ovary syndrome protects the pancreatic beta cell reserve preventing or delaying the occurrence of gestational diabetes. However, there are also doubts on the drug safety in pregnancy since it completely crosses the placenta.From this point of view, the inositol could represent an excellent alternative.Its role as insulin sensitizing agent is well documented on improving both the hormonal and reproductive parameters. However, the studies on its preconceptional use in preventing gestational diabetes are too limited though the first results are extremely encouraging.